Mercaptophenylboronic Acid-Activated Gold Nanoparticles as Nanoantibiotics against Multidrug-Resistant Bacteria

Wang, Le1,2,3; Yang, Junchuan4; Yang, Xinglong4; Hou, Qinghong2; Liu, Shaoqin1; Zheng, Wenfu4; Long, Yunze3; Jiang, Xingyu2

2020-11-18

10.1021/acsami.0c12597

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Multidrug-resistant (MDR) bacteria-induced infections are becoming challenging issues threatening human health and life. Current antibiotics can hardly tackle this problem. Herein, we present a strategy to prepare mercaptophenylboronic acid (MBA)-activated gold nanoparticles (Au NPs) as an antibacterial agent against MDR bacteria. Both Au NPs and MBA cannot serve as antibiotics. However, when MBA attaches on Au NPs, the Au_MBA NPs show potent antibacterial activities against Gram-positive MDR clinical isolates (e.g., MDR Staphyloccocus aureus, MDR S. aureus; MDR Staphyloccocus epidermidis, MDR S. epidermidis). Furthermore, Au_MBA NPs show an extremely high median lethal dose (LD50, i.v, 960 mg/kg), which is much higher than those of most of the clinically used antibiotics. As an application example, we dope Au_MBA NPs with electrospun poly(epsilon- caprolactone) (PCL)/gelatin nanofibrous membranes as wound dressings, which show striking ability to remedy S. aureus- or MDR S. aureus-infected full-thickness skin wounds on rats. Our study provides a novel strategy for treating MDR bacteria- infected wounds in a simple, low-cost, and efficient way, which holds promise for broad clinical applications.

gold nanoparticles antibacterial activity electrospun nanofibers wound healing mercaptophenylboronic acid multidrug-resistant bacteria

EI ; SCI

英语

通讯

National Natural Science Foundation of China[21761142006,21535001,81730051,81673039] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; National Key R&D Program of China[2018YFA0902600] ; Chinese Academy of Sciences["QYZDJ-SSW-SLH039","121D11KYSB20170026"] ; Shenzhen Bay Laboratory[SZBL2019062801004]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000592923100002

AMER CHEMICAL SOC

20204909564681

Antibiotics ; Bacteria ; Nanofibers ; Metal nanoparticles ; Fiber optic sensors

Medicine and Pharmacology:461.6 ; Fiber Optics:741.1.2 ; Nanotechnology:761 ; Solid State Physics:933

Web of Science

1.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
3.Qingdao Univ, Coll Phys, Collaborat Innovat Ctr Nanomat & Devices, Qingdao 266071, Peoples R China
4.Natl Ctr NanoSci & Technol, GBA Res Innovat Inst Nanotechnol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

Wang, Le,Yang, Junchuan,Yang, Xinglong,et al. Mercaptophenylboronic Acid-Activated Gold Nanoparticles as Nanoantibiotics against Multidrug-Resistant Bacteria[J]. ACS Applied Materials & Interfaces,2020,12(46):51148-51159.

Wang, Le.,Yang, Junchuan.,Yang, Xinglong.,Hou, Qinghong.,Liu, Shaoqin.,...&Jiang, Xingyu.(2020).Mercaptophenylboronic Acid-Activated Gold Nanoparticles as Nanoantibiotics against Multidrug-Resistant Bacteria.ACS Applied Materials & Interfaces,12(46),51148-51159.

Wang, Le,et al."Mercaptophenylboronic Acid-Activated Gold Nanoparticles as Nanoantibiotics against Multidrug-Resistant Bacteria".ACS Applied Materials & Interfaces 12.46(2020):51148-51159.