CT-guided localization techniques of small pulmonary nodules: a prospective non-randomized controlled study on pulmonary nodule localization needle and methylene blue staining with surgical glue

Kong, Jian1,2; Guo, Jianxi1,2; Zhang, Hua1,2; Li, Yong1,2; Wang, Guangsuo2,3; Zhang, Yanfang1,2

2020-11-01

10.21037/jtd-20-3147

Journal of Thoracic Disease   影响因子和分区

2072-1439

2077-6624

["Background: Thoracoscopic resection of small pulmonary nodules (SPNs) is challenging. Accurate preoperative computed tomography-guided localization of SPNs is key to successful rection. The aim of the present study was to evaluate the clinical value of a novel localization needle and methylene blue staining combined with surgical glue (MBSG) and to explore the risk factors for post-localization complications.","Methods: This prospective, non-randomized controlled study was conducted on 110 patients who received either MBSG or novel needle localization prior to video-assisted thoracoscopic surgery (VATS) from January 2019 to December 2019 at Shenzhen People's Hospital. The primary endpoints were the safety and the success rates of the 2 localization techniques. The secondary endpoints were operative time and feasibility.","Results: The 110 patients were categorized into 2 groups: the MBSG group (n=84) and the pulmonary nodule localization needle group (n=26). The success rate of pre-VATS localization was 100% in both groups. No deaths or serious complications occurred during localization. The rates of pneumothorax, pulmonary hemorrhage, and localization-induced cough were 38.1%, 25%, and 7.14%, respectively, in the MBSG group, and 26.92%, 19.23%, and 0%, respectively, in the pulmonary nodule localization needle group. Differences between the 2 groups were not statistically significant (P 0.05). The difference in operative time between the 2 groups was not statistically significant (P 0.05). Dye diffusion occurred in 2 patients in the MBSG group; however, it had no impact on VATS or on the pathological analysis. Neither displacement nor dislocation was observed in the pulmonary nodule localization needle group. Logistic regression analysis showed that the localization technique was an independent risk factor for total complications (odds ratio: 2.634, 95% confidence interval: 1.022-6.789, P<0.05).","Conclusions: Both techniques can localize SPNs effectively prior to VATS. The pulmonary nodule localization needle technique has a lower incidence of complications."]

Pulmonary nodule localization computed tomography-guided localization pulmonary nodule localization needle video-assisted thoracoscopic surgery (VATS)

SCI

英语

通讯

Shenzhen Key Medical Discipline Construction Fund[SZXK018] ; Subject Ability Improvement Project of Shenzhen Health and Fitness Commission, The Research and Development of Augmented Reality Navigation System for Precise Ablation of Liver Cancer[SZXJ2017066]

Respiratory System

Respiratory System

WOS:000614714500008

AME PUBL CO

Web of Science

1.Jinan Univ, Dept Intervent Radiol, Shenzhen Peoples Hosp, Second Clin Med Coll, Shenzhen 518020, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China
3.Jinan Univ, Dept Thorac Surg, Shenzhen Peoples Hosp, Second Clin Med Coll, Shenzhen 518020, Peoples R China

Kong, Jian,Guo, Jianxi,Zhang, Hua,et al. CT-guided localization techniques of small pulmonary nodules: a prospective non-randomized controlled study on pulmonary nodule localization needle and methylene blue staining with surgical glue[J]. Journal of Thoracic Disease,2020,12(11).

Kong, Jian,Guo, Jianxi,Zhang, Hua,Li, Yong,Wang, Guangsuo,&Zhang, Yanfang.(2020).CT-guided localization techniques of small pulmonary nodules: a prospective non-randomized controlled study on pulmonary nodule localization needle and methylene blue staining with surgical glue.Journal of Thoracic Disease,12(11).

Kong, Jian,et al."CT-guided localization techniques of small pulmonary nodules: a prospective non-randomized controlled study on pulmonary nodule localization needle and methylene blue staining with surgical glue".Journal of Thoracic Disease 12.11(2020).