Application of Structural and Functional Connectome Mismatch for Classification and Individualized Therapy in Alzheimer Disease

Ren，Huixia1,2; Zhu，Jin3; Su，Xiaolin4; Chen，Siyan4; Zeng，Silin4; Lan，Xiaoyong4; Zou，Liang Yu4; Sughrue，Michael E.5; Guo，Yi4

2020-11-23

10.3389/fpubh.2020.584430

Frontiers in Public Health   影响因子和分区

2296-2565

While machine learning approaches to analyzing Alzheimer disease connectome neuroimaging data have been studied, many have limited ability to provide insight in individual patterns of disease and lack the ability to provide actionable information about where in the brain a specific patient's disease is located. We studied a cohort of patients with Alzheimer disease who underwent resting state functional magnetic resonance imaging and diffusion tractography imaging. These images were processed, and a structural and functional connectivity matrix was generated using the HCP cortical and subcortical atlas. By generating a machine learning model, individual-level structural and functional anomalies detection and characterization were explored in this study. Our study found that structural disease burden in Alzheimer's patients is mainly focused in the subcortical structures and the Default mode network (DMN). Interestingly, functional anomalies were less consistent between individuals and less common in general in these patients. More intriguing was that some structural anomalies were noted in all patients in the study, namely a reduction in fibers involving parcellations in the right anterior cingulate. Alternately, the functional consequences of connectivity loss were cortical and variable. Integrated structural/functional connectomics might provide a useful tool for assessing AD progression, while few concerns have been made for analyzing the mismatch between these two. We performed a preliminary exploration into a set of Alzheimer disease data, intending to improve a personalized approach to understanding individual connectomes in an actionable manner. Specifically, we found that there were consistent patterns of white matter fiber loss, mainly focused around the DMN and deep subcortical structures, which were present in nearly all patients with clinical AD. Functional magnetic resonance imaging shows abnormal functional connectivity different within the patients, which may be used as the individual target for further therapeutic strategies making, like non-invasive stimulation technology.

Alzheimer's disease brain connectivity brain parcellation diffusion tractography imaging functional MRI machine learning

SCI ; SSCI

英语

通讯

Science and Technology planning project of Shenzhen Municipality[JCYJ20170818111012390] ; Sanming project of Medicine in Shenzhen[SYLY201905] ; Shenzhen health committee project[SZXJ2017034]

Public, Environmental & Occupational Health

Public, Environmental & Occupational Health

WOS:000595942400001

FRONTIERS MEDIA SA

2-s2.0-85097372762

Scopus

1.Department of Neurology,The Second Clinical Medical College,Shenzhen People's Hospital,Jinan University,Shenzhen,China
2.The First Affiliated Hospital,Jinan University,Guangzhou,China
3.Department of Medical Imaging,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China
4.Department of Neurology,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China
5.Centre for Minimally Invasive Neurosurgery,Prince of Wales Hospital,Sydney,Australia

Ren，Huixia,Zhu，Jin,Su，Xiaolin,et al. Application of Structural and Functional Connectome Mismatch for Classification and Individualized Therapy in Alzheimer Disease[J]. Frontiers in Public Health,2020,8.

Ren，Huixia.,Zhu，Jin.,Su，Xiaolin.,Chen，Siyan.,Zeng，Silin.,...&Guo，Yi.(2020).Application of Structural and Functional Connectome Mismatch for Classification and Individualized Therapy in Alzheimer Disease.Frontiers in Public Health,8.

Ren，Huixia,et al."Application of Structural and Functional Connectome Mismatch for Classification and Individualized Therapy in Alzheimer Disease".Frontiers in Public Health 8(2020).