南方科技大学知识苑(SUSTech KC): Optical Imaging and High-Accuracy Quantification of Intracellular Iron Contents

题名	Optical Imaging and High-Accuracy Quantification of Intracellular Iron Contents
作者	Ye，Dewen 1; Li，Mingxi 1; Xie，Yuanyuan 2; Chen，Bo 3; Han，Yuexia 1; Liu，Sijin 4; Wei，Qi Huo5,6 ; Gu，Ning 1
通讯作者	Gu，Ning
发表日期	2020
DOI	10.1002/smll.202005474
发表期刊	Small 影响因子和分区
ISSN	1613-6810
EISSN	1613-6829
卷号	17 期号:2
摘要	Precise quantification of intracellular iron contents is important to biomedical applications of magnetic nanoparticles. Current approaches for iron quantification rely on specialized instruments while most only yield iron quantities averaged over plenty of cells. Here, a simple and robust approach, combining digital optical microscopy with the Beer–Lambert's law, that allows for imaging stainable iron distribution in individual cells and the quantification of stainable iron contents with an unprecedented accuracy of femtogram per pixel, is presented. It is further shown that this approach enables studying of the internalization and reduction dynamics of super-paramagnetic iron oxide nanoparticles (SPIONs) by stem cells in single cell level.
关键词	Intracellular Iron Contents Optical Microscopy Spions Internalization And Reduction Stem Cell Super-paramagnetic Iron Oxide Nanoparticles (Spions)
相关链接	[Scopus记录]
收录类别	SCI ; EI
语种	英语
学校署名	其他
资助项目	National Key Research and Development Program of China[2017YFA0104301] ; National Natural Science Foundation of China[51832001]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000597413100001
出版者	WILEY-V C H VERLAG GMBH
EI入藏号	20205009619893
EI主题词	Nanomagnetics ; Cytology ; Optical data storage ; Optical microscopy ; Medical applications ; Iron oxides ; Paramagnetism ; Metal nanoparticles
EI分类号	Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Data Storage, Equipment and Techniques:722.1 ; Light/Optics:741.1 ; Nanotechnology:761 ; Inorganic Compounds:804.2
Scopus记录号	2-s2.0-85097388321
来源库	Scopus
引用统计	被引频次[WOS]：8
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/209827
专题	工学院_机械与能源工程系
作者单位	1.State Key Laboratory of Bioelectronics,Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science & Medical Engineering,Southeast University,Nanjing,210009,China 2.Center for Clinic Stem Cell Research,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,210008,China 3.Materials Science and Devices Institute,Suzhou University of Science and Technology,Suzhou,1 Kerui Road,215009,China 4.State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing,100085,China 5.Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China 6.Department of Physics,Nanjing Medical University,Nanjing,211166,China
推荐引用方式 GB/T 7714	Ye，Dewen,Li，Mingxi,Xie，Yuanyuan,et al. Optical Imaging and High-Accuracy Quantification of Intracellular Iron Contents[J]. Small,2020,17(2).
APA	Ye，Dewen.,Li，Mingxi.,Xie，Yuanyuan.,Chen，Bo.,Han，Yuexia.,...&Gu，Ning.(2020).Optical Imaging and High-Accuracy Quantification of Intracellular Iron Contents.Small,17(2).
MLA	Ye，Dewen,et al."Optical Imaging and High-Accuracy Quantification of Intracellular Iron Contents".Small 17.2(2020).

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