Kinetics of SARS-CoV-2 positivity of infected and recovered patients from a single center

Huang, Jia1,2; Zheng, Le3,4; Li, Zhen2; Hao, Shiying3,4; Ye, Fangfan1,2; Chen, Jun1; Gans, Hayley A.5; Yao, Xiaoming6; Liao, Jiayu7; Wang, Song1; Zeng, Manfei1; Qiu, Liping1; Li, Chunyang8,9; Whitin, John C.5; Tian, Lu10; Chubb, Henry5; Hwa, Kuo-Yuan11; Ceresnak, Scott R.5; Zhang, Wei8,9; Lu, Ying10; Maldonado, Yvonne A.5,12; McElhinney, Doff B.3,4; Sylvester, Karl G.2; Cohen, Harvey J.5; Liu, Lei1; Ling, Xuefeng B.2,4

2020-10-29

10.1038/s41598-020-75629-x

Scientific Reports   影响因子和分区

2045-2322

Recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive detection in infected but recovered individuals has been reported. Patients who have recovered from coronavirus disease 2019 (COVID-19) could profoundly impact the health care system. We sought to define the kinetics and relevance of PCR-positive recurrence during recovery from acute COVID-19 to better understand risks for prolonged infectivity and reinfection. A series of 414 patients with confirmed SARS-Cov-2 infection, at The Second Affiliated Hospital of Southern University of Science and Technology in Shenzhen, China from January 11 to April 23, 2020. Statistical analyses were performed of the clinical, laboratory, radiologic image, medical treatment, and clinical course of admission/quarantine/readmission data, and a recurrence predictive algorithm was developed. 16.7% recovered patients with PCR positive recurring one to three times, despite being in strict quarantine. Younger patients with mild pulmonary respiratory syndrome had higher risk of PCR positivity recurrence. The recurrence prediction model had an area under the ROC curve of 0.786. This case series provides characteristics of patients with recurrent SARS-CoV-2 positivity. Use of a prediction algorithm may identify patients at high risk of recurrent SARS-CoV-2 positivity and help to establish protocols for health policy.

SCI

英语

第一 ; 通讯

Sanming Project of Medicine in Shenzhen[SZSM201812065] ; National Natural Science Foundation of China[81501651]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000587692300026

NATURE RESEARCH

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 2, Natl Clin Res Ctr Infect Dis, Shenzhen, Guangdong, Peoples R China
2.Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA
3.Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA
4.Lucile Packard Childrens Hosp, Betty Irene Moore Childrens Heart Ctr, Clin & Translat Res Program, Palo Alto, CA USA
5.Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94305 USA
6.Sichuan Univ, West China Hosp, Translat Med Lab, Chengdu, Peoples R China
7.Univ Calif Riverside, Dept Bioengn, Riverside, CA 92521 USA
8.Sichuan Univ, West China Hosp, Biomed Big Data Ctr, Chengdu, Peoples R China
9.Sichuan Univ, Med Big Data Ctr, Chengdu, Peoples R China
10.Stanford Univ, Dept Biomed Data Sci, Stanford, CA 94305 USA
11.Univ Hong Kong, Dept Med, Hong Kong, Peoples R China
12.Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA

Huang, Jia,Zheng, Le,Li, Zhen,et al. Kinetics of SARS-CoV-2 positivity of infected and recovered patients from a single center[J]. Scientific Reports,2020,10(1).

Huang, Jia.,Zheng, Le.,Li, Zhen.,Hao, Shiying.,Ye, Fangfan.,...&Ling, Xuefeng B..(2020).Kinetics of SARS-CoV-2 positivity of infected and recovered patients from a single center.Scientific Reports,10(1).

Huang, Jia,et al."Kinetics of SARS-CoV-2 positivity of infected and recovered patients from a single center".Scientific Reports 10.1(2020).