南方科技大学知识苑(SUSTech KC): The Regulatory Mechanisms of Dynamin-Related Protein 1 in Tumor Development and Therapy

题名	The Regulatory Mechanisms of Dynamin-Related Protein 1 in Tumor Development and Therapy
作者	Han, Peiyu 1; Ren, Xinlu 2; Qu, Xiuxia 1; Meng, Yiteng 3,4
通讯作者	Meng, Yiteng
发表日期	2020-08-06
DOI	10.1089/cbr.2020.3791
发表期刊	CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 影响因子和分区
ISSN	1084-9785
摘要	Background: Various types of tumors are likely to acquire drug resistance over time. Hence, the development of novel therapies to overcome drug resistance is critical. Studies have demonstrated that drug resistance is closely associated with the dynamic regulation of mitochondria in tumor cells. The dynamin-related protein 1 (Drp1) is involved in the regulation of mitochondrial fission and plays an important role in maintaining mitochondrial morphology, function, and distribution. It is a key protein in mitochondrial quality control. Drp1 is a GTPase localized to the cytoplasm and is a potential target in cancer therapy. A variety of drugs targeting Drp1 have shown great promise in reducing the viability and proliferation of cancer cells. The dynamic regulation of Drp1-mediated mitochondria is closely associated with tumor development, and treatment.
关键词	antitumor effects apoptosis dynamin-related protein 1 (Drp1) invasion and migration mitophagy targeted drugs
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
WOS研究方向	Oncology ; Research & Experimental Medicine ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Oncology ; Medicine, Research & Experimental ; Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000586253200002
出版者	MARY ANN LIEBERT, INC
ESI学科分类	PHARMACOLOGY & TOXICOLOGY
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/210468
专题	南方科技大学第一附属医院
作者单位	1.Jiangnan Univ, Wuxi Sch Med, Wuxi, Jiangsu, Peoples R China 2.Nanchang Univ, Dept Clin Med, Queen Mary Coll, Nanchang, Jiangxi, Peoples R China 3.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gastroenterol, Shenzhen, Guangdong, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Han, Peiyu,Ren, Xinlu,Qu, Xiuxia,et al. The Regulatory Mechanisms of Dynamin-Related Protein 1 in Tumor Development and Therapy[J]. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,2020.
APA	Han, Peiyu,Ren, Xinlu,Qu, Xiuxia,&Meng, Yiteng.(2020).The Regulatory Mechanisms of Dynamin-Related Protein 1 in Tumor Development and Therapy.CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS.
MLA	Han, Peiyu,et al."The Regulatory Mechanisms of Dynamin-Related Protein 1 in Tumor Development and Therapy".CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2020).