Regenerating Hair in Prevascularized Tissue Space Formed by a Controllable Foreign Body Reaction

Yang, Lunan1,2; Miao, Yong1; Liu, Yuqing2; Chen, Shiyi2; Chen, Yuxin1; Liu, Weiwen1; Wang, Jin1; Zhong, Wen3; Wang, Quan4,5; Hu, Zhiqi1; Xing, Malcolm2

2020-11-23

10.1002/adfm.202007483

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Intracutaneous transplantation of trichogenic cells is a currently endorsed strategy to realize hair regeneration in vivo. However, skin is not the most advantageous transplant site due to the robust mechanical property and deficient physiological perfusion. Herein, a subcutaneous space made of prevascularized collagen fibers (PVCF) generated by controlling the duration of in situ foreign body reaction is reported. In contrast to skin, an optimally preprogrammed PVCF presents a larger tissue volume (171 mm(3)), low Young's modulus (1/2-fold), high flexibility high mechanical energy dissipation rate (1.3-fold), highly permeable surface structure, and plentiful vascular network. Remarkably, cells transplanted into PVCF suffer less apoptosis and necrosis, and generate more mature hairs (approximate to 289 per site) than that in intracutaneous transplantation (approximate to 177 per site). The RNA-sequencing profiling indicates similar trends under molecular level. This work provides a promising strategy to improve graft site microenvironment physiologically and mechanically, with a low-cost and simple fabrication process.

collagen fibers foreign body reaction graft site microenvironment hair regeneration prevascularization

SCI ; EI

英语

NI论文

其他

National Natural Science Foundation of China[81701929] ; Guangdong Basic and Applied Basic Research Foundation[2019A1515012170]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000591314100001

WILEY-V C H VERLAG GMBH

20204809556866

Collagen ; Energy dissipation ; Surface structure ; Tissue regeneration ; Elastic moduli ; Biomechanics ; Cell death

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biomechanics, Bionics and Biomimetics:461.3 ; Biology:461.9 ; Energy Losses (industrial and residential):525.4 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Materials Science:951

MATERIALS SCIENCE

Web of Science

1.Southern Med Univ, Nanfang Hosp, Dept Plast & Aesthet Surg, Guangzhou 510515, Guangdong, Peoples R China
2.Univ Manitoba, Dept Mech Engn, 75A Chancellors Circle, Winnipeg, MB R3T 2N2, Canada
3.Univ Manitoba, Dept Biosyst Engn, 75A Chancellors Circle, Winnipeg, MB R3T 2N2, Canada
4.Shantou Univ, Dept Civil Engn, Shantou 515063, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Dept Mech & Aerosp Engn, Shenzhen 518055, Peoples R China

Yang, Lunan,Miao, Yong,Liu, Yuqing,et al. Regenerating Hair in Prevascularized Tissue Space Formed by a Controllable Foreign Body Reaction[J]. ADVANCED FUNCTIONAL MATERIALS,2020,31(8).

Yang, Lunan.,Miao, Yong.,Liu, Yuqing.,Chen, Shiyi.,Chen, Yuxin.,...&Xing, Malcolm.(2020).Regenerating Hair in Prevascularized Tissue Space Formed by a Controllable Foreign Body Reaction.ADVANCED FUNCTIONAL MATERIALS,31(8).

Yang, Lunan,et al."Regenerating Hair in Prevascularized Tissue Space Formed by a Controllable Foreign Body Reaction".ADVANCED FUNCTIONAL MATERIALS 31.8(2020).