| 题名 | A narrative review of research advances in mesenchymal stem cell therapy for asthma |
| 作者 | |
| 通讯作者 | Chen, Rongchang; Qiu, Chen |
| 发表日期 | 2020-11
|
| DOI | |
| 发表期刊 | |
| ISSN | 2305-5839
|
| EISSN | 2305-5847
|
| 卷号 | 8期号:21 |
| 摘要 | Asthma is a chronic inflammatory disease of the airways that involves multiple cells, including inflammatory cells, structural cells, and cellular components. Glucocorticoids and beta-receptor agonists are still the first choices for asthma treatment. However, the asthma symptoms may still be poorly controlled in some patients after an optimal treatment. Mesenchymal stem cells (MSCs) are characterized by the potential for multi-directional differentiation and can exert immunomodulatory and anti-inflammatory effects. Its role in treating asthma has increasingly been recognized in recent years. In this review article, we sought to summarize the recent advances in the therapeutic effects of MSCs on several types of asthma and explain the relevant mechanisms. Articles on asthma treatment with MSCs as of January 2020 were searched in PubMed, Google Scholar, and Web of Science databases. It was found that MSCs have therapeutic effects on allergic asthma, non-allergic asthma and occupational asthma; gene-modified or pretreated MSCs improves the therapeutic effects of MSCs in asthma; MSC-derived conditioned medium or extracellular vesicles possess the considerable curative effect as MSC on asthma; and MSCs exert their therapeutic effects on asthma by restoring Th1/Th2 balance, reversing Th17/Tregs imbalance, inhibiting DC maturation, and promoting the switch of M1 to M2 and repairing epithelial injury. Thus, MSCs may be a promising treatment for asthma. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 通讯
|
| 资助项目 | National Natural Science Foundation of China[NSFC:81770028]
; Natural Science Foundation of Guangdong[2018A030310011]
|
| WOS研究方向 | Oncology
; Research & Experimental Medicine
|
| WOS类目 | Oncology
; Medicine, Research & Experimental
|
| WOS记录号 | WOS:000590057700023
|
| 出版者 | |
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：10
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/210497 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Resp & Crit Care Med, Shenzhen 518020, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Inst Resp Dis, Shenzhen 518020, Peoples R China |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Yu, Xiu,Yu, Li,Guo, Bingxin,et al. A narrative review of research advances in mesenchymal stem cell therapy for asthma[J]. Annals of Translational Medicine,2020,8(21).
|
| APA |
Yu, Xiu,Yu, Li,Guo, Bingxin,Chen, Rongchang,&Qiu, Chen.(2020).A narrative review of research advances in mesenchymal stem cell therapy for asthma.Annals of Translational Medicine,8(21).
|
| MLA |
Yu, Xiu,et al."A narrative review of research advances in mesenchymal stem cell therapy for asthma".Annals of Translational Medicine 8.21(2020).
|
| 条目包含的文件 | 条目无相关文件。 | |||||
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