Upconversion nanoparticles coated with molecularly imprinted polymers for specific sensing

Yang，Ling1,2; Chen，Xiaorui1; Ma，Ping'an1,2; Jin，Dayong3,4; Zhou，Jiajia4; He，Hao3; Cheng，Ziyong1,2; Lin，Jun1,2

2020-12-21

10.1039/d0dt03555f

DALTON TRANSACTIONS   影响因子和分区

1477-9226

1477-9234

The development of fluorescent sensors based on lanthanide-doped luminescent nanoparticles has increased their application in biomarker detection. Lanthanide-doped upconversion nanoparticles (UCNPs) have been explored as one of the most promising sensors owing to their merits such as excellent photostability, zero background auto-fluorescence, and reduced side effects of near-infrared triggered treatments. However, traditional upconversion luminescence assay based on direct Fluorescence Resonance Energy Transfer (FRET) between the target molecules and surface of UCNPs encounters low detection accuracy due to superficial adsorption interactions. In this work, we use a molecularly imprinting technique to achieve the specific interaction between UCNPs and molecules for accurate sensing. We demonstrate this by synthesizing a nanostructure with a molecularly imprinted polymer at the surface of UCNPs, in which the imprinted cavities can specifically capture the target molecule of rhodamine B. The upconversion signal changes in relation to the molecule concentration due to FRET. Quantitative analysis shows that the fluorescence-quenching rate is consistent with the Stern-Volmer equation, resulting in a limit of detection of 6.27 μg mL-1. Our fluorescence sensing approach integrates the advantages of both nonlinear upconversion and molecular imprinting technologies, showing great potential for the detection of specific molecules.

SCI ; EI

英语

其他

Science and Technology Cooperation Fund between Chinese and Australian Governments[2017YFE0132300] ; National Natural Science Foundation of China[NSFC 51720105015][51872282][51922097][51772288]

Chemistry

Chemistry, Inorganic & Nuclear

WOS:000599093600018

ROYAL SOC CHEMISTRY

20205209685742

Energy transfer ; Forster resonance energy transfer ; Infrared devices ; Molecules ; Nanoparticles ; Polymers ; Quenching ; Rare earth elements

Heat Treatment Processes:537.1 ; Rare Earth Metals:547.2 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Polymeric Materials:815.1 ; Atomic and Molecular Physics:931.3 ; Solid State Physics:933

CHEMISTRY

2-s2.0-85098073436

Scopus

1.State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,China
2.University of Science and Technology of China,Hefei,230026,China
3.Department of Biomedical Engineering Institute for Biomedical Materials and Devices,Southern University of Science and Technology,Shenzhen, Guangdong,518055,China
4.Faculty of Science,Institute for Biomedical Materials and Devices,University of Technology,Sydney,2007,Australia

Yang，Ling,Chen，Xiaorui,Ma，Ping'an,et al. Upconversion nanoparticles coated with molecularly imprinted polymers for specific sensing[J]. DALTON TRANSACTIONS,2020,49(47):17200-17206.

Yang，Ling.,Chen，Xiaorui.,Ma，Ping'an.,Jin，Dayong.,Zhou，Jiajia.,...&Lin，Jun.(2020).Upconversion nanoparticles coated with molecularly imprinted polymers for specific sensing.DALTON TRANSACTIONS,49(47),17200-17206.

Yang，Ling,et al."Upconversion nanoparticles coated with molecularly imprinted polymers for specific sensing".DALTON TRANSACTIONS 49.47(2020):17200-17206.