南方科技大学知识苑(SUSTech KC): The mechanism of CAIX in tumor therapy and its influence on patient prognosis

题名	The mechanism of CAIX in tumor therapy and its influence on patient prognosis
作者	Zhang，Haosheng; Xu，Gang; Wu，Shihai; Gong，Long; Zhou，Yayan; Li，Xianming
发表日期	2020
DOI	10.19193/0393-6384_2020_6_580
发表期刊	Acta Medica Mediterranea 影响因子和分区
ISSN	0393-6384
EISSN	2283-9720
卷号	36 期号:6页码:3661-3667
摘要	The carbonic anhydrase IX (CAIX) family (originally named MN/G250) is a type of zinc-containing metalloenzyme family of cell surface transmembrane proteins. Many studies worldwide have demonstrated that CAIX is a protease that rapidly converts CO2 and H2O into H+ and HCO3-. Its main mechanism in cells is to act as a "proton pump" in similar cells to maintain the weak alkalinity and extracellular acidic microenvironment of tumour cells. The positive expression of CAIX protein can be detected in many tumours such as nasopharyngeal carcinoma, cervical cancer, breast cancer, rectal cancer and gastric cancer, and is related to the occurrence and development of the tumour as well as the therapeutic effect and prognosis of patients. Therefore, the mechanism of CAIX in tumour cells is described in this paper, and the relationship between the expression of CAIX in cells and tumour treatment and prognosis is also discussed.
关键词	Carbonic anhydrase IX (CAIX) Chemotherapy sensitivity PH Radiosensitivity
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一
Scopus记录号	2-s2.0-85097787999
来源库	Scopus
引用统计	被引频次[WOS]：0
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/210781
专题	南方科技大学第一附属医院
作者单位	Department of Radiation Oncology,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen, Guangdong,518020,China
第一作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Zhang，Haosheng,Xu，Gang,Wu，Shihai,et al. The mechanism of CAIX in tumor therapy and its influence on patient prognosis[J]. Acta Medica Mediterranea,2020,36(6):3661-3667.
APA	Zhang，Haosheng,Xu，Gang,Wu，Shihai,Gong，Long,Zhou，Yayan,&Li，Xianming.(2020).The mechanism of CAIX in tumor therapy and its influence on patient prognosis.Acta Medica Mediterranea,36(6),3661-3667.
MLA	Zhang，Haosheng,et al."The mechanism of CAIX in tumor therapy and its influence on patient prognosis".Acta Medica Mediterranea 36.6(2020):3661-3667.