Recent development of nanoparticle-assisted metabolites analysis with mass spectrometry

Li，Hua1; Li，Ting2,3; Shi，Xianzhe2; Xu，Guowang2

2021-01-11

10.1016/j.chroma.2020.461785

JOURNAL OF CHROMATOGRAPHY A   影响因子和分区

0021-9673

1873-3778

Metabolomics systematically studies the changes of metabolites in biological systems in the temporal or spatial dimensions. It is a challenging task for comprehensive analysis of metabolomics because of diverse physicochemical properties and wide concentration distribution of metabolites. Used as enrichment sorbents, chemoselective probes, chromatographic stationary phases, MS ionization matrix, nanomaterials play excellent roles in improving the selectivity, separation performance, detection sensitivity and identification efficiency of metabolites when mass spectrometry is employed as the detection technique. This review summarized the recent development of nanoparticle-assisted metabolites analysis in terms of assisting the pretreatment of biological samples, improving the separation performance and enhancing the MALDI-MS detection.

chemoselective probe enrichment MALDI imaging Metabolomics nanoparticles stationary phase

SCI ; EI

英语

第一

National Natural Science Foundation of China[21904057] ; National Key Research and Development Program of China[2019YFC1605100] ; DICP, CAS[DICPQIBEBT UN201806]

Biochemistry & Molecular Biology ; Chemistry

Biochemical Research Methods ; Chemistry, Analytical

WOS:000607570900005

ELSEVIER

20205209680189

Probes ; Metabolites ; Physicochemical properties ; Molecular imaging ; Biomolecules ; Mass spectrometry

Biomedical Engineering:461.1 ; Biology:461.9 ; Imaging Techniques:746 ; Nanotechnology:761 ; Chemistry:801 ; Biochemistry:801.2 ; Physical Chemistry:801.4 ; Solid State Physics:933

CHEMISTRY

2-s2.0-85098453238

Scopus

1.SUSTech Core Research Facilities,Southern University of Science and Technology,Shenzhen,518055,China
2.CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,116023,China
3.Zhang Dayu School of Chemistry,Dalian University of Technology,Dalian,116024,China

Li，Hua,Li，Ting,Shi，Xianzhe,et al. Recent development of nanoparticle-assisted metabolites analysis with mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2021,1636.

Li，Hua,Li，Ting,Shi，Xianzhe,&Xu，Guowang.(2021).Recent development of nanoparticle-assisted metabolites analysis with mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1636.

Li，Hua,et al."Recent development of nanoparticle-assisted metabolites analysis with mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1636(2021).