Bioinspired membrane provides periosteum-mimetic microenvironment for accelerating vascularized bone regeneration

Yang，Gaojie1,2,4; Liu，Haoming1,2,3; Cui，Yi4; Li，Jiaqi1,2; Zhou，Xuan1,2; Wang，Nuoxin5; Wu，Feige1,2; Li，Yan1,2; Liu，Yu1,2; Jiang，Xingyu5; Zhang，Shengmin1,2

2021

10.1016/j.biomaterials.2020.120561

BIOMATERIALS   影响因子和分区

0142-9612

1878-5905

Periosteum plays a pivotal role in vascularization, ossification and remodeling during the healing process of bone injury. However, there are few studies focused on the construction of artificial implants with periosteum-mimetic effect. To emulate the primary role of natural periosteum or endosteal tissues in bone regeneration, here we provide a functional biomimetic membrane with micropatterns of site-specific biomineralization. The micropattern is generated by using printed hydroxyapatite nanoparticles (HANPs), combined with selective growth of biomineralized apatite and in situ coprecipitation with growth factors. The biomimetic membrane can sustainably provide a periosteum-mimetic microenvironment, such as long-term topographical guidance for cell recruitment and induced cell differentiation, by releasing calcium phosphate and growth factors. We demonstrated that rat mesenchymal stem cells (rMSCs) on such biomimetic membrane exhibited highly aligned organization, leading to enhanced angiogenesis and osteogenesis. In the rat calvarial defect model, our biomimetic membranes with biomineralized micropatterns could significantly enhance vascularized ossification and accelerate new bone formation. The current work suggests that the functionally biomimetic membranes with specific biomineralized micropatterns can be a promising alternative to periosteal autografts, with great potential for bench-to-bedside translation in orthopedics.

Biomimetic periosteum Bone regeneration Cell manipulation Hydroxyapatite Micropattern

SCI ; EI

英语

其他

National Natural Science Foundation of China[31430029,31870960,81471792,81802138,30870624] ; National Key R&D Program of China[2018YFC1105701]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000611868900001

ELSEVIER SCI LTD

20205109655585

Cell culture ; Membranes ; Tissue regeneration ; Biomimetics ; Biomineralization ; Hydroxyapatite ; Molecular biology ; Stem cells ; Calcium phosphate ; Bone

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biotechnology:461.8 ; Biology:461.9 ; Minerals:482.2 ; Biochemistry:801.2 ; Inorganic Compounds:804.2 ; Materials Science:951

MATERIALS SCIENCE

2-s2.0-85097719757

Scopus

1.Advanced Biomaterials and Tissue Engineering Center,Huazhong University of Science and Technology,Wuhan,430074,China
2.Department of Biomedical Engineering,Huazhong University of Science and Technology,Wuhan,430074,China
3.Department of Orthopedics,Xiangya Hospital,Central South University,Changsha,410008,China
4.Media Lab and McGovern Institute,Massachusetts Institute of Technology,Cambridge,02139,United States
5.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China

Yang，Gaojie,Liu，Haoming,Cui，Yi,et al. Bioinspired membrane provides periosteum-mimetic microenvironment for accelerating vascularized bone regeneration[J]. BIOMATERIALS,2021,268.

Yang，Gaojie.,Liu，Haoming.,Cui，Yi.,Li，Jiaqi.,Zhou，Xuan.,...&Zhang，Shengmin.(2021).Bioinspired membrane provides periosteum-mimetic microenvironment for accelerating vascularized bone regeneration.BIOMATERIALS,268.

Yang，Gaojie,et al."Bioinspired membrane provides periosteum-mimetic microenvironment for accelerating vascularized bone regeneration".BIOMATERIALS 268(2021).