Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol-Modified Gold Nanoparticles by Reducing their Sizes

Xie，Yangzhouyun1; Yang，Junchuan1; Zhang，Jiangjiang1; Zheng，Wenfu1,2; Jiang，Xingyu1

2020-12-21

10.1002/anie.202008584

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   影响因子和分区

1433-7851

1521-3773

Adequately decorated gold nanoparticles (GNPs) have excellent antibiotic activities against multidrug-resistant (MDR) bacteria. Nanoparticles exhibiting Gram selective antibacterial actions are beneficial to precise therapy. Here, we present a strategy to tune the antibacterial spectrum of a small molecule (4,6-diamino-2-pyrimidinethiol, DAPT)-modified GNPs (DAPT-GNPs, DGNPs) by adjusting their sizes. Compared to large (ca. 14 nm diameter) DGNPs (lDGNPs) and medium-sized (3–4 nm diameter) DGNPs (mDGNPs), which have no antibacterial effect or only target Gram-negative (G−) bacteria, ultrasmall DGNPs (uDGNPs, <2 nm) have a broad antibacterial spectrum, especially showing an over 60-fold increase in antibacterial efficacy against Gram-positive (G+) bacteria. Moreover, the uDGNPs-functionalized scaffolds (agarose gel) can serve as general wound dressings for healing burnt infections. Our strategy is insightful for exploring properties of the nanomaterials and their applications.

antibacterial activity ultrasmall gold nanoparticles wound dressing

SCI ; EI

英语

NI论文

第一 ; 通讯

Chemistry

Chemistry, Multidisciplinary

WOS:000598243300013

WILEY-V C H VERLAG GMBH

20205109623638

Bacteria ; Fiber optic sensors ; Metal nanoparticles ; Scaffolds

Construction Equipment:405.1 ; Fiber Optics:741.1.2 ; Nanotechnology:761

CHEMISTRY

2-s2.0-85097264206

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District,518055,China
2.GBA Research Innovation Institute for Nanotechnology,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for NanoScience and Technology,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China

Xie，Yangzhouyun,Yang，Junchuan,Zhang，Jiangjiang,et al. Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol-Modified Gold Nanoparticles by Reducing their Sizes[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020,59(52):23471-23475.

Xie，Yangzhouyun,Yang，Junchuan,Zhang，Jiangjiang,Zheng，Wenfu,&Jiang，Xingyu.(2020).Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol-Modified Gold Nanoparticles by Reducing their Sizes.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,59(52),23471-23475.

Xie，Yangzhouyun,et al."Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol-Modified Gold Nanoparticles by Reducing their Sizes".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 59.52(2020):23471-23475.