Corpora Cavernos invasion vs. Corpus Spongiosum invasion in Penile Cancer: A systematic review and meta-analysis

Li, Zaishang1,2,3; Li, Xueying4; Lam, Wayne5; Cao, Yabing6; Geng, Jiunhung7,8,9; Ornellas, Antonio Augusto10; Zhou, Fangjian11,12,13; Han, Hui11,12,13

2021

10.7150/jca.56504

Journal of Cancer   影响因子和分区

1837-9664

["Objective: Changes were made in the 8th edition of the American Joint Committee on Cancer (AJCC) staging system according to cavernosum invasion for penile squamous cell carcinoma. This study aimed to determine the difference of prognostic validity between corpora cavernosa (CC) invasion and corpus spongiosum (CS) invasion.","Methods: In this study, we searched PubMed, Cochrane CENTRAL, and Embase to select English-language articles until July 15, 2020. Pooled analyses of hazard ratios (HRs) and odds ratios (ORs) were performed.","Results: Eleven studies including 3692 cases were included in the final ananlysis (1431 cases with CC and 1360 cases with CS). According to the anatomical structure, the pooled results demonstrated that patients with CC invasion had a similar rate of LNM to those with CS invasion (OR 1.34, 95% confidence interval (CI) 0.97-1.86; P=0.076). However, patients with CC invasion had a higher rate of lymph node metastasis (LNM) than those with CS invasion according to the 8th edition tumor stage (OR 1.58, 95% CI 1.14-2.21; P<0.001). Regarding survival, patients with CS invasion obtained a significantly better cancer-specific survival (CSS) (HR, 0.67; 95% CI, 0.46-0.96; P=0.030), but not in overall survival (OS) (HR: 1.30; 95% CI, 0.52-3.20; P=0.585) than those with CC invasion. No a significant publication bias was observed by Begg's and Egger's tests.","Conclusions: The systematic comparison suggests that patients with CS invasion had better CSS than those with CC invasion. CC invasion was associated with a high risk of LNM. The conclusions should be validated by large-scale studies."]

penile cancer prognosis meta-analysis lymph node metastasis stage

SCI

英语

其他

National Natural Science Foundation of China[81772755,81902610]

Oncology

Oncology

WOS:000623069400011

IVYSPRING INT PUBL

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Urol, Shenzhen 518060, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Dept Urol, Shenzhen 518060, Guangdong, Peoples R China
3.Minimally Invas Urol Shenzhen Res & Dev Ctr Med E, Dept Urol, Shenzhen 518060, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Affiliated Hosp 7, Dept Oncol, Shenzhen 518107, Guangdong, Peoples R China
5.Univ Hong Kong, Queen Marys Hosp, Dept Surg, Div Urol, Hong Kong 999077, Peoples R China
6.Hosp Kiang Wu, Dept Oncol, Taipa 999078, Macao, Peoples R China
7.Kaohsiung Municipal Hsiaokang Hosp, Dept Urol, Kaohsiung 000800, Taiwan
8.Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung 000800, Taiwan
9.Kaohsiung Med Univ, T-000800 Kaohsiung, Taiwan
10.Brazilian Natl Inst Canc, Dept Urol, BR-20230130 Rio De Janeiro, Brazil
11.Sun Yat Sen Univ, Canc Ctr, Dept Urol, Guangzhou 510060, Guangdong, Peoples R China
12.State Key Lab Oncol South China, Guangzhou 510060, Guangdong, Peoples R China
13.Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China

Li, Zaishang,Li, Xueying,Lam, Wayne,et al. Corpora Cavernos invasion vs. Corpus Spongiosum invasion in Penile Cancer: A systematic review and meta-analysis[J]. Journal of Cancer,2021,12(7).

Li, Zaishang.,Li, Xueying.,Lam, Wayne.,Cao, Yabing.,Geng, Jiunhung.,...&Han, Hui.(2021).Corpora Cavernos invasion vs. Corpus Spongiosum invasion in Penile Cancer: A systematic review and meta-analysis.Journal of Cancer,12(7).

Li, Zaishang,et al."Corpora Cavernos invasion vs. Corpus Spongiosum invasion in Penile Cancer: A systematic review and meta-analysis".Journal of Cancer 12.7(2021).