Integrated Microfluidic Synthesis of Aptamer Functionalized Biozeolitic Imidazolate Framework (BioZIF-8) Targeting Lymph Node and Tumor

Balachandran, Yekkuni L.; Li, Xuanyu; Jiang, Xingyu

2021-02-10

10.1021/acs.nanolett.0c04053

NANO LETTERS   影响因子和分区

1530-6984

1530-6992

Targeted delivery of therapeutic molecules using nanomaterials is desired to elicit specific responses toward diseases. Such an integrated synthesis of functional material using a microfluidic approach is a great challenge. Functional metal organic frameworks (MOFs) with unique structural diversity possess a complicated synthesis procedure thereby requiring a modest, straightforward approach to synthesize size-controllable MOFs. Here, we develop an integrated microfluidic chip to synthesize the aptamer-modified biozeolitic imidazolate framework (BioZIF-8) to target the lymph node and tumor. The first stage of the microfluidic chip forms the ZIF-8 encapsulating biomolecules (bovine serum albumin, small interfering ribonucleic acid, and doxorubicin). The second stage modifies the surface of BioZIF-8 with the aptamer. Our approach reduces the overall synthesis time (similar to 3 mg/10 min against 15 h for the conventional two-step method) and encapsulates a higher number of biomolecules. The microfluidic approach realizes the rapid and fine-tuned synthesis of functional MOFs integrated into one-step.

Microfluidics BioZIF-8 MOFs drug delivery tumor lymph nodes

SCI ; EI

英语

NI论文

第一 ; 通讯

National Key R&D Program of China["2018YFA0902600","2017YFA0205901"] ; National Natural Science Foundation of China[21535001,81730051,21761142006] ; Chinese Academy of Sciences["QYZDJ-SSW-SLH039","121D11KYSB20170026","XDA16020902"]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000619638600019

AMER CHEMICAL SOC

20211010027560

Biomolecules ; Fluidic devices ; Functional materials ; Mammals ; Metal-Organic Frameworks ; Organometallics ; RNA ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Hydraulic Equipment and Machinery:632.2 ; Microfluidics:632.5.1 ; Organic Compounds:804.1 ; Materials Science:951

MATERIALS SCIENCE

Web of Science

Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China

Balachandran, Yekkuni L.,Li, Xuanyu,Jiang, Xingyu. Integrated Microfluidic Synthesis of Aptamer Functionalized Biozeolitic Imidazolate Framework (BioZIF-8) Targeting Lymph Node and Tumor[J]. NANO LETTERS,2021,21(3):1335-1344.

Balachandran, Yekkuni L.,Li, Xuanyu,&Jiang, Xingyu.(2021).Integrated Microfluidic Synthesis of Aptamer Functionalized Biozeolitic Imidazolate Framework (BioZIF-8) Targeting Lymph Node and Tumor.NANO LETTERS,21(3),1335-1344.

Balachandran, Yekkuni L.,et al."Integrated Microfluidic Synthesis of Aptamer Functionalized Biozeolitic Imidazolate Framework (BioZIF-8) Targeting Lymph Node and Tumor".NANO LETTERS 21.3(2021):1335-1344.