Light-Triggered Nitric Oxide Release by a Photosensitizer to Combat Bacterial Biofilm Infections

Zhao, Zhennan1; Li, Huinan1; Tao, Xuan1; Xie, Yanxuan1; Yang, Liang2; Mao, Zong-Wan1; Xia, Wei1

2021

10.1002/chem.202004698

CHEMISTRY-A EUROPEAN JOURNAL   影响因子和分区

0947-6539

1521-3765

Bacterial biofilms are a serious global health concern, often responsible for persistent infections. New strategies to prevent and treat bacterial infections by eradication of the biofilms are urgently needed. A novel ruthenium-based compound is reported in this study that functions as both a boronic acid-decorated photosensitizer (PS) and a light-triggered nitric oxide (NO) releasing agent. The compound can selectively attach to the bacterial membrane and biofilms and it is highly potent at eradicating Pseudomonas aeruginosa biofilms through the simultaneous release of NO and reactive oxygen species (ROS). The compound, which is more effective than clinical antibiotic tobramycin, also has excellent bacterial specificity and shows no significant cytotoxicity to human cells. The results reveal potential applications of this innovative dual-functional photoactivated ruthenium compound to combat bacterial biofilm infections.

antibacterial agents biofilm photodynamic therapy photolysis ruthenium

SCI ; EI

英语

其他

National Natural Science Foundation of China[22022706,21877131,91953117] ; Natural Science Foundation of Guangdong Province, China[2019A1515011156] ; Ministry of Education of China[IRT17R111]

Chemistry

Chemistry, Multidisciplinary

WOS:000608268100001

WILEY-V C H VERLAG GMBH

20210309792468

Antibiotics ; Biofilms ; Nitric oxide ; Photosensitizers

Medicine and Pharmacology:461.6 ; Biomaterials (including synthetics):462.5 ; Light/Optics:741.1 ; Inorganic Compounds:804.2

CHEMISTRY

Web of Science

1.Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China

Zhao, Zhennan,Li, Huinan,Tao, Xuan,et al. Light-Triggered Nitric Oxide Release by a Photosensitizer to Combat Bacterial Biofilm Infections[J]. CHEMISTRY-A EUROPEAN JOURNAL,2021,27(17):5453-5460.

Zhao, Zhennan.,Li, Huinan.,Tao, Xuan.,Xie, Yanxuan.,Yang, Liang.,...&Xia, Wei.(2021).Light-Triggered Nitric Oxide Release by a Photosensitizer to Combat Bacterial Biofilm Infections.CHEMISTRY-A EUROPEAN JOURNAL,27(17),5453-5460.

Zhao, Zhennan,et al."Light-Triggered Nitric Oxide Release by a Photosensitizer to Combat Bacterial Biofilm Infections".CHEMISTRY-A EUROPEAN JOURNAL 27.17(2021):5453-5460.