Age and gender dependence of liver diffusion parameters and the possibility that intravoxel incoherent motion modeling of the perfusion component is constrained by the diffusion component

Huang, Hua1; Zheng, Cun-Jing2; Wang, Li-Fei1; Che-Nordin, Nazmi2; Wang, Yi Xiang J.2

2021-03-01

10.1002/nbm.4449

NMR IN BIOMEDICINE   影响因子和分区

0952-3480

1099-1492

The aim of this study was to establish reference values for middle-aged subjects and to investigate the age and gender dependence of liver diffusion MRI parameters. The IVIM type of liver diffusion scan was based on a single-shot spin-echo-type echo-planar sequence using a 1.5 T magnet with 16 b-values. Diffusion-derived vessel density (DDVD)(b0b2) or DDVD(b0b10) was the signal difference between b = 0 and b = 2 (or b = 10) s/mm(2) images after removing visible vessels. IVIM analysis was performed with full fitting and segmented fitting, and with a threshold b-value of 60 or 200 s/mm(2), and fitting started from b = 2 s/mm(2). Thirty-one men (age range: 25-71 years) and 26 men (age: 22-69 years) had DDVD and IVIM analysis, respectively, while 37 women (age: 20-71 years) and 36 women (age: 20-71 years) had DDVD and IVIM analysis, respectively. DDVD results showed a significant age-related reduction for women. IVIM results for full fitting showed excellent agreement with those for segmented fitting using a threshold b of 60 s/mm(2), but this was less good for results with a threshold b of 200 s/mm(2). As age increased, female subjects' D-slow measure showed a significant reduction, while their PF and D-fast measures showed a significant increase. For the age group of 40-55 years, DDVD(b0b2), DDVD(b0b10), D-slow, PF and D-fast were 12.26 +/- 3.90 au/pixel, 16.95 +/- 5.45 au/pixel, 1.072 +/- 0.067 (10(-3) mm(2)/s), 0.141 +/- 0.025 and 61.0 +/- 14.0 (10(-3) mm(2)/s) for men, and 13.35 +/- 3.6 au/pixel, 17.20 +/- 3.62 au/pixel, 1.069 +/- 0.074 (10(-3) mm(2)/s), 0.119 +/- 0.014 and 57.1 +/- 13.2 (10(-3) mm(2)/s) for women, respectively. DDVD measure of this study suggest that aging is associated with a reduction in liver perfusion. There is a possibility that a lower D-slow measure is associated with artificially higher PF and D-fast measures, and that IVIM modeling of the perfusion component is constrained by the diffusion component.

aging biophysical mechanisms of MR diffusion liver diffusion‐ weighted imaging hepatobiliary intravoxel incoherent motion

SCI ; EI

英语

第一

Hong Kong GRF[14109218] ; Sanming Project of Medicine in Shenzhen[SZSM201612053]

Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy

Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy

WOS:000600886400001

WILEY

CLINICAL MEDICINE

Web of Science

1.Southern Univ Sci & Technol, Natl Clin Res Ctr Infect Dis, Affiliated Hosp 2, Peoples Hosp Shenzhen 3,Dept Radiol, Shenzhen, Guangdong, Peoples R China
2.Chinese Univ Hong Kong, Fac Med, Dept Imaging & Intervent Radiol, Shatin, Hong Kong, Peoples R China

Huang, Hua,Zheng, Cun-Jing,Wang, Li-Fei,et al. Age and gender dependence of liver diffusion parameters and the possibility that intravoxel incoherent motion modeling of the perfusion component is constrained by the diffusion component[J]. NMR IN BIOMEDICINE,2021,34(3).

Huang, Hua,Zheng, Cun-Jing,Wang, Li-Fei,Che-Nordin, Nazmi,&Wang, Yi Xiang J..(2021).Age and gender dependence of liver diffusion parameters and the possibility that intravoxel incoherent motion modeling of the perfusion component is constrained by the diffusion component.NMR IN BIOMEDICINE,34(3).

Huang, Hua,et al."Age and gender dependence of liver diffusion parameters and the possibility that intravoxel incoherent motion modeling of the perfusion component is constrained by the diffusion component".NMR IN BIOMEDICINE 34.3(2021).