南方科技大学知识苑(SUSTech KC): Transcriptome profiling of different types of human respiratory tract cells infected by SARS-CoV-2 highlight an unique role for inflammatory and interferon response

题名	Transcriptome profiling of different types of human respiratory tract cells infected by SARS-CoV-2 highlight an unique role for inflammatory and interferon response
作者	Yang, Minghui 1; Lei, Luping 2; Cao, Qiumei 2; Yang, Yang 1 ; Wang, Jun 1 ; Jiang, Xiao 1; Huang, Kun1 ; Lai, Jinzhi 1; Qing, Ling 1; Wang, Yu 3; Liu, Yingxia 1
通讯作者	Wang, Yu; Liu, Yingxia
发表日期	2021
DOI	10.1080/26895293.2021.1879280
发表期刊	All Life 影响因子和分区
ISSN	2689-5293
EISSN	2689-5307
卷号	14 期号:1
摘要	The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) at the end of 2019 has caused a large global outbreak and now become a major public health issue. However, there is currently a lack of data underlying how the human host interacts with SARS-CoV-2 virus. In the current study, We performed Venn-analysis, Gene ontology (GO), KEGG pathway analysis and Protein-protein interaction analysis of whole transcriptome studies with the aim of clarifying the genes and pathways potentially altered during human respiratory tract cell infection with SARS-CoV-2. We found 36 overlapping upregulated genes among different types of cells after viral infection. Further functional enrichment analysis revealed these Differential Expressed Genes (DEGs) are most likely involved in biological processes related to inflammatory response and response to cytokine, cell component related to extracellular space and I-kappa B/NF-kappa B complex, molecular function related to protein binding and cytokine activity. KEGG pathways analysis highlighted altered conical and casual pathways related to TNF, NF-kappa B, Cytokine-cytokine receptor interaction and IL-17 signaling pathways during SARS CoV-2 infection with CXCL1, CXCL2, CXCL3, CXCL8, CXCL10, IL32, CX3CL1, CCL20, IRF1, NFKB2 and NFKB1A up-regulated which may explain the inflammatory cytokine storms associated with severe cases of COVID-19.
关键词	SARS-CoV-2 transcriptomics gene ontology pathway analysis inflammatory response
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Shenzhen Natural Science Foundation[JCYJ20190809152415652] ; China Postdoctoral Science Foundation[2019M660836] ; Shenzhen Key Technology Research Project[JSGG20200207161928126] ; National Science and Technology Major Project["2018ZX10711001","2017ZX10103011","2018ZX09711003","2020YFC0841700"] ; Shenzhen Science and Technology Research and Development Project[202002073000001]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000618755400001
出版者	TAYLOR & FRANCIS LTD
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/221080
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis,State Key Discipline, Shenzhen Key Lab Pathogen & Immun,Hosp Affiliated, Shenzhen, Peoples R China 2.Capital Med Univ, Beijing TongRen Hosp, Beijing, Peoples R China 3.Beijing Geriatr Hosp, Beijing, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Yang, Minghui,Lei, Luping,Cao, Qiumei,et al. Transcriptome profiling of different types of human respiratory tract cells infected by SARS-CoV-2 highlight an unique role for inflammatory and interferon response[J]. All Life,2021,14(1).
APA	Yang, Minghui.,Lei, Luping.,Cao, Qiumei.,Yang, Yang.,Wang, Jun.,...&Liu, Yingxia.(2021).Transcriptome profiling of different types of human respiratory tract cells infected by SARS-CoV-2 highlight an unique role for inflammatory and interferon response.All Life,14(1).
MLA	Yang, Minghui,et al."Transcriptome profiling of different types of human respiratory tract cells infected by SARS-CoV-2 highlight an unique role for inflammatory and interferon response".All Life 14.1(2021).