南方科技大学知识苑(SUSTech KC): Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma

题名	Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma
作者	Chen, Wenbiao 1; Tang, Donge 1; Tang, Dongxin 2; Dai, Yong 1
通讯作者	Tang, Dongxin; Dai, Yong
发表日期	2020-10-23
DOI	10.1038/s41419-020-03109-1
发表期刊	Cell Death & Disease 影响因子和分区
ISSN	2041-4889
卷号	11 期号:10
摘要	Inactivation of tumor suppressor gene played critical roles in the development and progression of human hepatocellular carcinoma (HCC). Zic family member 4 (ZIC4) is transcription factor and plays an important role in the developmental process. However, the expression and biological role of ZIC4 in HCC is poorly understood. Here, bioinformatics analysis based on The Cancer Genome Atlas ( TCGA) database revealed an aberrant hypermethylation of ZIC4 in HCC. ZIC4 is frequently hypermethylated in promoter region and down expressed in HCC cells and tissues. Functionally, ZIC4 inhibition facilitated the proliferation, migration, invasion, and epithelialmesenchymal transition (EMT) in vitro and in vivo. Conversely, ZIC4 overexpression reduced proliferation and invasiveness of HCC cells. In addition, ZIC4 inhibition rescued the antitumor effect induced by enhancer of zeste homolog 2 (EZH2) knockdown or EZH2 inhibitor. Mechanistically, EZH2 knockdown or EZH2 inhibitor reduced the enrichment of EZH2 and H3K27me3 in ZIC4 promoter region and leading to the upregulation of ZIC4. Altogether, these data indicate that epigenetic silencing of ZIC4 by EZH2 mediated H3K27me3 is an important mechanism in HCC and provide a new therapeutic target for the treatment of hepatocellular carcinoma disease.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China[81671596] ; National Science Foundation for Young Scientists of China[31700795] ; science and technology plan of Shenzhen["JCYJ20180302145337935","JCYJ20180306140810282"]
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:000619350800005
出版者	SPRINGERNATURE
来源库	Web of Science
引用统计	被引频次[WOS]：6
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/221089
专题	南方科技大学第一附属医院
作者单位	1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp,Dept Clin Med Res Ctr, Affiliated Hosp 1,Southern Univ Sci & Technol, Shenzhen 518020, Peoples R China 2.Guiyang Univ Chinese Med, Dept Sci & Educ, Affiliated Hosp 1, Guiyang 550001, Guizhou, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Chen, Wenbiao,Tang, Donge,Tang, Dongxin,et al. Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma[J]. Cell Death & Disease,2020,11(10).
APA	Chen, Wenbiao,Tang, Donge,Tang, Dongxin,&Dai, Yong.(2020).Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma.Cell Death & Disease,11(10).
MLA	Chen, Wenbiao,et al."Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma".Cell Death & Disease 11.10(2020).