Combining Blood-Based Biomarkers to Predict Mortality of Sepsis at Arrival at the Emergency Department

Xie, Yinjing1,2; Li, Binbin2,3; Lin, Ying1,2; Shi, Fei2,3; Chen, Weibu1,2; Wu, Wenyuan1,2; Zhang, Wenjia1,2; Fei, Yun1,2; Zou, Shiqing1,2; Yao, Can2,3

2021-02-25

10.12659/MSM.929527

MEDICAL SCIENCE MONITOR   影响因子和分区

1643-3750

["Background: Our aim was to determine a useful combination of blood biomarkers that can predict 28-day mortality of sepsis upon arrival at the Emergency Department (ED).","Material/Methods: Based on Sepsis-3.0, 90 sepsis patients were enrolled and divided into survivor and nonsurvivor groups with day 28 as the study end point. After comparing the demographic data and clinical characteristics of patients, we evaluated the predictive validity of a combination of markers including interleukin-6 (IL-6), procalcitonin (PCT), and lactate at arrival at the ED. Independent risk factors were found by using univariate and multivariate logistic regression analyses, and the prognostic value of markers was determined by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve.","Results: There were 67 (74.4%) survivors and 23 (25.6%) nonsurvivors. The levels of IL-6 (survivors vs nonsurvivors: median 205.30 vs 3499.00 pg/mL, P=0.012) and lactate (survivors vs nonsurvivors: median 2.37 vs 5.77 mmol/L, P=0.003) were significantly lower in survivor group compared with the nonsurvivor group. Markers including IL-6, PCT, lactate, and neutrophil-to-white blood cell ratio (NWR) were independent risk factors in predicting 28-day mortality due to sepsis. The combination of these 4 markers provided the best predictive performance for 28-day mortality of patients with sepsis, on arrival at the ED (AUC of 0.823, 95% confidence interval [CI] 0.723-0.924), and its accuracy, specificity, and sensitivity were 74.4% (95% CI 64.0-82.8%), 91% (95% CI 80.9-96.3%), and 65% (95% CI 42.8-82.8%), respectively.","Conclusions: The combination of IL-6, PCT, lactate, and NWR measurements is a potential predictor of 28-day mortality for patients with sepsis, at arrival at the ED. Further research is needed to confirm our findings."]

C-Reactive Protein Interleukin-6 Lactic Acid Mortality Sepsis

SCI

英语

通讯

Research & Experimental Medicine

Medicine, Research & Experimental

WOS:000621656500001

INT SCIENTIFIC INFORMATION, INC

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Lab Dept, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
3.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Emergency Dept, Shenzhen, Guangdong, Peoples R China

Xie, Yinjing,Li, Binbin,Lin, Ying,et al. Combining Blood-Based Biomarkers to Predict Mortality of Sepsis at Arrival at the Emergency Department[J]. MEDICAL SCIENCE MONITOR,2021,27.

Xie, Yinjing.,Li, Binbin.,Lin, Ying.,Shi, Fei.,Chen, Weibu.,...&Yao, Can.(2021).Combining Blood-Based Biomarkers to Predict Mortality of Sepsis at Arrival at the Emergency Department.MEDICAL SCIENCE MONITOR,27.

Xie, Yinjing,et al."Combining Blood-Based Biomarkers to Predict Mortality of Sepsis at Arrival at the Emergency Department".MEDICAL SCIENCE MONITOR 27(2021).