Intratumoral CD45(+)CD71(+) erythroid cells induce immune tolerance and predict tumor recurrence in hepatocellular carcinoma

Chen, Jie1,2,3; Qiao, Yi-Dan1,2,3; Li, Xing1,2; Xu, Jian-Liang4; Ye, Qing-Jian5; Jiang, Nan6,7; Zhang, Hui3; Wu, Xiang-Yuan1,2

2021-02-28

10.1016/j.canlet.2020.12.003

CANCER LETTERS   影响因子和分区

0304-3835

1872-7980

CD45(+)CD71(+) erythroid cells generated through splenic extramedullary erythropoiesis have recently been found to suppress anti-infection and tumor immunity in neonates and adults with malignances. However, their role in tumor microenvironment has not been investigated. In the present study, we found that the number of CD45(+)CD71(+) erythroid cells was significantly elevated in hepatocellular carcinoma (HCC) tissues compared to that in paratumor region and circulation. Additionally, they were more abundant in HCC tissues compared to some immune suppressive cells as well as CD45(-)CD71(+) erythroid cells. CD45(+)CD71(+) erythroid cells suppressed T cells through generation of reactive oxygen species, IL-10, and TGF-beta in a paracrine and cell-cell contact manner, and their suppressive effect was stronger than that of myeloid-derived suppressor cells. The abundance of CD45(+)CD71(+) erythroid cells in tumor tissue, as illustrated via immunofluorescence, predicted disease-free survival and overall survival, and its prognostic value was better than that of Cancer of the Liver Italian Program score. This study demonstrated that accumulation of intratumoral CD45(+)CD71(+) erythroid cells in HCC tissues could play a superior immunosuppressive role in tumor microenvironment and may serve as a valuable biomarker to predict recurrence of HCC.

Erythroid cells Immune tolerance Hepatocellular carcinoma Prognosis

SCI

英语

其他

National Natural Science Foundation of China[81972677,81700645] ; Guangdong Basic and Applied Basic Research Foundation["2019A1515012198","2017A030313537"] ; Guangzhou Science and Technology Project[201904010461] ; Special Fundamental Research Fund of Sun Yat-sen University[19ykpy17] ; National Special Research Program of China for Important Infectious Diseases["2018ZX10302103","2017ZX10202102"] ; Important Key Program of the Natural Science Foundation of China[81730060] ; Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program[2019TQ05Y266]

Oncology

Oncology

WOS:000604424500012

ELSEVIER IRELAND LTD

CLINICAL MEDICINE

Web of Science

1.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Med Oncol, 600 Tianhe Rd, Guangzhou 510630, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 3, Guangdong Key Lab Liver Dis Res, 600 Tianhe Rd, Guangzhou 510630, Peoples R China
3.Sun Yat Sen Univ, Zhongshan Sch Med, Minist Educ, Inst Human Virol,Key Lab Trop Dis Control,Guangdo, 74 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Hepatobiliary Surg, 600 Tianhe Rd, Guangzhou 510630, Peoples R China
5.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Gynaecol, 600 Tianhe Rd, Guangzhou 510630, Peoples R China
6.Southern Univ Sci & Technol, Affiliated Hosp 2, Dept Transplantat, 29th Bulan Rd, Shenzhen 510623, Peoples R China
7.Third Peoples Hosp Shenzhen, 29th Bulan Rd, Shenzhen 510623, Peoples R China

Chen, Jie,Qiao, Yi-Dan,Li, Xing,et al. Intratumoral CD45(+)CD71(+) erythroid cells induce immune tolerance and predict tumor recurrence in hepatocellular carcinoma[J]. CANCER LETTERS,2021,499.

Chen, Jie.,Qiao, Yi-Dan.,Li, Xing.,Xu, Jian-Liang.,Ye, Qing-Jian.,...&Wu, Xiang-Yuan.(2021).Intratumoral CD45(+)CD71(+) erythroid cells induce immune tolerance and predict tumor recurrence in hepatocellular carcinoma.CANCER LETTERS,499.

Chen, Jie,et al."Intratumoral CD45(+)CD71(+) erythroid cells induce immune tolerance and predict tumor recurrence in hepatocellular carcinoma".CANCER LETTERS 499(2021).