Body-weight fluctuation and risk of diabetes in older adults: The China Health and Retirement Longitudinal Study (CHARLS)

Cai, Xue1; Qiu, Shanhu2; Liu, Shuling1; Lu, Yanhui1; Luo, Dan1; Li, Ruxue1; Li, Mingzi1

2020-11-01

10.1016/j.diabres.2020.108419

DIABETES RESEARCH AND CLINICAL PRACTICE   影响因子和分区

0168-8227

1872-8227

["Aims: Body-weight fluctuation is associated with an increased risk of all-cause mortality. Yet no studies investigate its association with risk of diabetes in adults aged >= 60 years. This study aimed to address this issue.","Methods: A total of 1,565 participants free of diabetes at baseline in the CHARLS were followed for 4-year. Body-weight was collected at baseline and every 2-year. Body-weight fluctuation was primarily calculated as the root-mean-square-error deviation from the regression line of body-weights against years. The risk of diabetes was estimated using logistic regression analysis.","Results: During the 4-year follow-up, 153 participants developed diabetes. The risk of diabetes was increased by 23% (odds ratio [OR] 1.23, 95% confidence interval [CI] 1.06 to 1.43) per every 1-standard deviation higher of body-weight fluctuation after controlling for cardiovascular risk factors. The association appeared pronounced among participants with poor physical performance (both P < 0.03). Participants with overweight/obesity and a high body-weight fluctuation had the largest increase in the risk for diabetes (OR 3.03). Body-weight fluctuation correlated with hemoglobin A1c and white blood cells at follow-up or their change scores from baseline, especially in females (all P < 0.02).","Conclusions: Body-weight fluctuation led to an increased risk of diabetes in adults aged 60 years. (c) 2020 Elsevier B.V. All rights reserved."]

Body-weight fluctuation Diabetes Elderly

SCI

英语

其他

National Institute on Aging of the National Institute of Health["R01-AG037031-01","R01AG037031-03S1","R03-TW008358-01","R21-AG03137201"] ; Natural Science Foundation of China[70910107022,71130002] ; Knowledge for Change Program at the World Bank[7159234]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000598123600019

ELSEVIER IRELAND LTD

CLINICAL MEDICINE

Web of Science

1.Peking Univ, Sch Nursing, Xueyuan Rd 38, Beijing, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Dept Endocrinol,Clin Med Coll Jinan Univ 2, Shenzhen, Peoples R China

Cai, Xue,Qiu, Shanhu,Liu, Shuling,et al. Body-weight fluctuation and risk of diabetes in older adults: The China Health and Retirement Longitudinal Study (CHARLS)[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2020,169.

Cai, Xue.,Qiu, Shanhu.,Liu, Shuling.,Lu, Yanhui.,Luo, Dan.,...&Li, Mingzi.(2020).Body-weight fluctuation and risk of diabetes in older adults: The China Health and Retirement Longitudinal Study (CHARLS).DIABETES RESEARCH AND CLINICAL PRACTICE,169.

Cai, Xue,et al."Body-weight fluctuation and risk of diabetes in older adults: The China Health and Retirement Longitudinal Study (CHARLS)".DIABETES RESEARCH AND CLINICAL PRACTICE 169(2020).