IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma

Yang, Ying1; Wang, Jin2,3; Xu, Shihai2,3; Lv, Wen2,3; Shi, Fei2,3; Shan, Aijun2,3

2021

10.1515/tnsci-2021-0002

Translational Neuroscience   影响因子和分区

2081-3856

2081-6936

["Background - In cancer, kappa B-interacting protein (IKBIP) has rarely been reported. This study aimed at investigating its expression pattern and biological function in brain glioma at the transcriptional level.","Methods - We selected 301 glioma patients with microarray data from CGGA database and 697 glioma patients with RNAseq data from TCGA database. Transcriptional data and clinical data of 998 samples were analyzed. Statistical analysis and figure generating were performed with R language.","Results - We found that IKBIP expression showed positive correlation with WHO grade of glioma. IKBIP was increased in isocitrate dehydrogenase (IDH) wild type and mesenchymal molecular subtype of glioma. Gene ontology analysis demonstrated that IKBIP was profoundly associated with extracellular matrix organization, cell-substrate adhesion and response to wounding in both pan-glioma and glioblastoma. Subsequent gene set enrichment analysis revealed that IKBIP was particularly correlated with epithelial-to-mesenchymal transition (EMT). To further elucidate the relationship between IKBIP and EMT, we performed gene set variation analysis to screen the EMT-related signaling pathways and found that IKBIP expression was significantly associated with PI3K/AKT, hypoxia and TGF-beta pathway. Moreover, IKBIP expression was found to be synergistic with key biomarkers of EMT, especially with N-cadherin, vimentin, snail, slug and TWIST1. Finally, higher IKBIP indicated significantly shorter survival for glioma patients.","Conclusions - IKBIP was associated with more aggressive phenotypes of gliomas. Furthermore, IKBIP was significantly involved in EMT and could serve as an independent prognosticator in glioma."]

glioma IKBIP epithelial-to-mesenchymal transition prognosis

SCI

英语

其他

Medical Scientific Research Foundation of Shenzhen Health Commission[szfz2018022] ; Shenzhen Science and Technology Innovation Foundation[JCYJ20190806150005453] ; Futian Public Welfare Scientific Research Project[FTWS2020099]

Neurosciences & Neurology

Neurosciences

WOS:000609207200001

DE GRUYTER POLAND SP Z O O

Web of Science

1.Futian Women & Children Hlth Inst, Dept Pediat, Shenzhen 518045, Peoples R China
2.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Emergency, Shenzhen 518020, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China

Yang, Ying,Wang, Jin,Xu, Shihai,et al. IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma[J]. Translational Neuroscience,2021,12(1).

Yang, Ying,Wang, Jin,Xu, Shihai,Lv, Wen,Shi, Fei,&Shan, Aijun.(2021).IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma.Translational Neuroscience,12(1).

Yang, Ying,et al."IKBIP is a novel EMT-related biomarker and predicts poor survival in glioma".Translational Neuroscience 12.1(2021).