Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer The STARS Phase 3 Randomized Clinical Trial

Huang, He1; Feng, Yan-Ling1; Wan, Ting1; Zhang, Yan-Na1; Cao, Xin-Ping1; Huang, Yong-Wen1; Xiong, Ying1; Huang, Xin1; Zheng, Min1; Li, Yan-Fang1; Li, Jun-Dong1; Chen, Guan-Di2; Li, Hu3; Chen, Yi-Le4; Ma, Li-Guo5; Yang, Hong-Ying6; Li, Li7; Yao, Shu-Zhong8; Ye, Wei-Jun1; Tu, Hua1; Huang, Qi-Dan1; Liang, Li-Zhi1; Liu, Fu-Yuan1; Liu, Qing1; Liu, Ji-Hong1

2021

10.1001/jamaoncol.2020.7168

JAMA Oncology   影响因子和分区

2374-2437

2374-2445

["IMPORTANCE There is no current consensus on the role of chemotherapy in addition to radiation for postoperative adjuvant treatment of patients with early-stage cervical cancer with adverse pathological factors.","OBJECTIVE To evaluate the clinical benefits of sequential chemoradiation (SCRT) and concurrent chemoradiation (CCRT) compared with radiation alone (RT) as a postoperative adjuvant treatment in early-stage cervical cancer.","DESIGN, SETTING, AND PARTICIPANTS After radical hysterectomy at 1 of 8 participating hospitals in China, patients with FIGO (International Federation of Gynecology and Obstetrics) stage IB to IIA cervical cancer with adverse pathological factors were randomized 1:1:1 to receive adjuvant RT, CCRT, or SCRT. Data were collected from February 2008 to December 2018.","INTERVENTIONS Patients received adjuvant RT (total dose, 45-50 Gy), CCRT (weekly cisplatin, 30-40 mg/m(2)), or SCRT (cisplatin, 60-75 mg/m(2), plus paclitaxel, 135-175 mg/m(2)) in a 21-day cycle, given 2 cycles before and 2 cycles after radiotherapy, respectively.","MAIN OUTCOMES AND MEASURES The primary end point was the rate of disease-free survival (DFS) at 3 years.","RESULTS A total of 1048 women (median [range] age, 48 [23-65] years) were included in the analysis (350 in the RT group, 345 in the CCRT group, and 353 in the SCRT group). Baseline demographic and disease characteristics were balanced among the treatment groups except that the rate of lymph node involvement was lowest in the RT group (18.3%). In the intention-to-treat population, SCRT was associated with a higher rate of DFS than RT (3-year rate, 90.0% vs 82.0%; hazard ratio [HR], 0.52; 95% CI, 0.35-0.76) and CCRT (90.0% vs 85.0%; HR, 0.65; 95% CI, 0.44-0.96). Treatment with SCRT also decreased cancer death risk compared with RT (5-year rate, 92.0% vs 88.0%; HR, 0.58; 95% CI, 0.35-0.95) after adjustment for lymph node involvement. However, neither DFS nor cancer death risk was different among patients treated with CCRT or RT.","CONCLUSIONS AND RELEVANCE In this randomized clinical trial, conducted in a postoperative adjuvant treatment setting, SCRT, rather than CCRT, resulted in a higher DFS and lower risk of cancer death than RT among women with early-stage cervical cancer."]

SCI

英语

ESI高被引

其他

Sun Yat-sen University Clinical Research 5010 Program[2007041]

Oncology

Oncology

WOS:000607741100005

AMER MEDICAL ASSOC

Web of Science

1.Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China
2.Guangdong Prov Peoples Hosp, Guangzhou, Guangdong, Peoples R China
3.Guangzhou Panyu Cent Hosp, Guangzhou, Guangdong, Peoples R China
4.Hunan Canc Hosp, Changsha, Hunan, Peoples R China
5.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
6.Kunming Med Univ, Affiliated Hosp 3, Yunnan Canc Hosp, Kunming, Yunnan, Peoples R China
7.Guangxi Med Univ, Affiliated Tumor Hosp, Nanning, Peoples R China
8.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

Huang, He,Feng, Yan-Ling,Wan, Ting,et al. Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer The STARS Phase 3 Randomized Clinical Trial[J]. JAMA Oncology,2021.

Huang, He.,Feng, Yan-Ling.,Wan, Ting.,Zhang, Yan-Na.,Cao, Xin-Ping.,...&Liu, Ji-Hong.(2021).Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer The STARS Phase 3 Randomized Clinical Trial.JAMA Oncology.

Huang, He,et al."Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer The STARS Phase 3 Randomized Clinical Trial".JAMA Oncology (2021).