| 题名 | Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System |
| 作者 | |
| 通讯作者 | Hayashi, Yasunori |
| 发表日期 | 2021-02-03
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| DOI | |
| 发表期刊 | |
| ISSN | 0270-6474
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| EISSN | 1529-2401
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| 卷号 | 41期号:5 |
| 摘要 | Molecules within cells are segregated into functional domains to form various organelles. While some of those organelles are delimited by lipid membranes demarcating their constituents, others lack a membrane enclosure. Recently, liquid-liquid phase separation (LLPS) revolutionized our view of how segregation of macromolecules can produce membraneless organelles. While the concept of LLPS has been well studied in the areas of soft matter physics and polymer chemistry, its significance has only recently been recognized in the field of biology. It occurs typically between macromolecules that have multivalent interactions. Interestingly, these features are present in many molecules that exert key functions within neurons. In this review, we cover recent topics of LLPS in different contexts of neuronal physiology and pathology. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| 资助项目 | Ministry of Education, Culture, Sports, Science and Technology, Japan["18H04733","18H05434"]
; Simons Foundation[510178]
; Research Grant Council of Hong Kong["AoE-M09-12","C6004-17G"]
; Human Frontier Science Program[RGP0020/2019]
; Telethon Career Award[TCP15011]
; Alzheimer Association's Grant[AARG-17-505136]
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| WOS研究方向 | Neurosciences & Neurology
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| WOS类目 | Neurosciences
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| WOS记录号 | WOS:000616763400004
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| 出版者 | |
| ESI学科分类 | NEUROSCIENCE & BEHAVIOR
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| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：41
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/221191 |
| 专题 | 生命科学学院 |
| 作者单位 | 1.Kyoto Univ, Grad Sch Med, Dept Pharmacol, Kyoto 6068501, Japan 2.Columbia Univ, Zuckerman Mind Brain Behav Inst, New York, NY 10027 USA 3.Ist Ricovero & Cura Carattere Sci, Mario Negri Inst Pharmacol Res, Dept Neurosci, I-20156 Milan, Italy 4.Univ Dundee, Sch Life Sci, Cell & Dev Biol, Dundee DD1 5EH, Scotland 5.Hong Kong Univ Sci & Technol, Div Life Sci, Kowloon, Hong Kong, Peoples R China 6.Southern Univ Sci & Technol, Sch Life Sci, Shenzhen 518055, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Hayashi, Yasunori,Ford, Lenzie K.,Fioriti, Luana,et al. Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System[J]. JOURNAL OF NEUROSCIENCE,2021,41(5).
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| APA |
Hayashi, Yasunori,Ford, Lenzie K.,Fioriti, Luana,McGurk, Leeanne,&Zhang, Mingjie.(2021).Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System.JOURNAL OF NEUROSCIENCE,41(5).
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| MLA |
Hayashi, Yasunori,et al."Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System".JOURNAL OF NEUROSCIENCE 41.5(2021).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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