Liposomes Encapsulating Neoantigens and Black Phosphorus Quantum Dots for Enhancing Photothermal Immunotherapy

Zhang, Jinxie1; Chen, Xiuli3; Xue, Tianyuan4; Cheng, Qinzhen1; Ye, Xinyu3,5; Wang, Changshan2; Yu, Yongkang1; Ji, Xiaoyuan1; Wu, Meiying1; Zhang, Xudong4; Zheng, Yi2; Wu, Benqing2; Liang, Xin1,2; Mei, Lin1,6

2020-09-01

10.1166/jbn.2020.2977

Journal of Biomedical Nanotechnology   影响因子和分区

1550-7033

1550-7041

Colorectal cancer frustrates with high relapse after the traditional treatment including surgery and chemotherapy. Neoantigen-based therapeutic vaccine has achieved high response rate in the clinical trials rising the immunotherapy as a promising alternative for colorectal cancer. Herein, colon cancer cells derived neoantigen peptide Adpgk were employed to be co-encapsulated with black phosphorus quantum dots into liposome (Adpgk-BPQDs-liposome) as therapeutic vaccine. Adpgk-BPQDs-liposome were dispersed in F127 gel containing GM-CSF. The heat generated by black phosphorus (BP) under 808 nm near-infrared laser irradiation accelerates the F127 gel ablation and the release of GM-CSF, which recruit APC cells and prime the native T cells. The tumor bearing mice received the programmed cell death protein 1 (PD-1) checkpoint blockade antibody combined with photo-thermal gel intensively prevented the tumor progress. Furthermore, the tumor infiltrating CD8(+) T cells were significantly increased which lead to the elimination of the tumor.

Neoantigen Black Phosphorous Immunotherapy Photothermal Colon Cancer

SCI

英语

其他

National Natural Science Foundation of China[81801843,81971737,31971268] ; Natural Science Foundation of Guangdong Province[2020A1515010802] ; Science, Technology & Innovation Commission of Shenzhen Municipality["JCYJ20180507183428877","JCYJ20170818162637217","JCYJ20180507181654186"] ; University of Chinese Academy of Sciences-Shenzhen Hospital Research Funding[HRF-2020004] ; Natural Science Foundation of Guangdong Province United Fund[2019A1515110395]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:000608371300001

AMER SCIENTIFIC PUBLISHERS

Web of Science

1.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Guangdong, Peoples R China
2.Univ Chinese Acad Sci, Shenzhen Hosp, Ctr Expt Med CEM, Shenzhen 518000, Peoples R China
3.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
4.Sun Yat Sen Univ, Sch Med, Guangzhou 510275, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
6.Chinese Acad Med Sci & Peking Union Med Coll, Inst Biomed Engn, Key Lab Biomat & Nanotechnol Canc Immunotherapy, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R China

Zhang, Jinxie,Chen, Xiuli,Xue, Tianyuan,et al. Liposomes Encapsulating Neoantigens and Black Phosphorus Quantum Dots for Enhancing Photothermal Immunotherapy[J]. Journal of Biomedical Nanotechnology,2020,16(9).

Zhang, Jinxie.,Chen, Xiuli.,Xue, Tianyuan.,Cheng, Qinzhen.,Ye, Xinyu.,...&Mei, Lin.(2020).Liposomes Encapsulating Neoantigens and Black Phosphorus Quantum Dots for Enhancing Photothermal Immunotherapy.Journal of Biomedical Nanotechnology,16(9).

Zhang, Jinxie,et al."Liposomes Encapsulating Neoantigens and Black Phosphorus Quantum Dots for Enhancing Photothermal Immunotherapy".Journal of Biomedical Nanotechnology 16.9(2020).