南方科技大学知识苑(SUSTech KC): Virus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes

题名	Virus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes
作者	Chen, Pei-Fen 1,2; Yu, Xia-Xia 3; Liu, Yi-Peng 1; Ren, Di 4; Shen, Min 1 ; Huang, Bing-Sheng 5; Gao, Jun-Ling 6; Huang, Zheng-Yang 3; Wu, Ming 7; Wang, Wei-Yan 1; Chen, Li 1 ; Shi, Xia 1; Wang, Zhao-Qing 1; Liu, Ying-Xia 1; Liu, Lei1 ; Liu, Yong 4
通讯作者	Liu, Yong
发表日期	2020-12-26
DOI	10.12998/wjcc.v8.i24.6252
发表期刊	World Journal of Clinical Cases 影响因子和分区
ISSN	2307-8960
卷号	8 期号:24
摘要	["BACKGROUND","Understanding a virus shedding patterns in body fluids/secretions is important to determine the samples to be used for diagnosis and to formulate infection control measures.","AIM","To investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding patterns and its risk factors.","METHODS","All laboratory-confirmed coronavirus disease 2019 patients with complete medical records admitted to the Shenzhen Third People's Hospital from January 28, 2020 to March 8, 2020 were included. Among 145 patients (54.5% males; median age, 46.1 years), three (2.1%) died. The bronco-alveolar lavage fluid (BALF) had the highest virus load compared with the other samples. The viral load peaked at admission (3.3 x 10(8) copies) and sharply decreased 10 d after admission.","RESULTS","The viral load was associated with prolonged intensive care unit (ICU) duration. Patients in the ICU had significantly longer shedding time compared to those in the wards (P < 0.0001). Age > 60 years [hazard ratio (HR) = 0.6; 95% confidence interval (CI): 0.4-0.9] was an independent risk factor for SARS-CoV-2 shedding, while chloroquine (HR = 22.8; 95%CI: 2.3-224.6) was a protective factor.","CONCLUSION","BALF had the highest SARS-CoV-2 load. Elderly patients had higher virus loads, which was associated with a prolonged ICU stay. Chloroquine was associated with shorter shedding duration and increased the chance of viral negativity."]
关键词	COVID-19 Virus shedding Viral load Patient outcome China Infectious disease
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一
资助项目	Startup Fund for Youth Faculty of Shenzhen University[2018009]
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
WOS记录号	WOS:000603646900004
出版者	BAISHIDENG PUBLISHING GROUP INC
来源库	Web of Science
引用统计	被引频次[WOS]：5
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/221211
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2,Dept Resp Dis,Shenzhen Key Lab Pathol & Im, Natl Clin Res Ctr Infect Dis,State Key Discipline, Shenzhen 518114, Guangdong, Peoples R China 2.Linzhi Peoples Hosp, Dept Infect Dis, Linzhi 86000, Tibet Autonomou, Peoples R China 3.Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn, Shenzhen 518060, Guangdong, Peoples R China 4.Second Peoples Hosp Shenzhen, Expert Panel Shenzhen 2019 nCoV Pneumonia, Shenzhen 518035, Guangdong, Peoples R China 5.Shenzhen Univ, Hlth Sci Ctr, Sch Biomed Engn, Med AI Lab, Shenzhen 518060, Guangdong, Peoples R China 6.Univ Hong Kong, Ctr Buddhist Studies, Buddhism & Sci Res Lab, Pokfulam, Hong Kong 999077, Peoples R China 7.Second Peoples Hosp Shenzhen, ICU, Shenzhen 518035, Guangdong, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Chen, Pei-Fen,Yu, Xia-Xia,Liu, Yi-Peng,et al. Virus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes[J]. World Journal of Clinical Cases,2020,8(24).
APA	Chen, Pei-Fen.,Yu, Xia-Xia.,Liu, Yi-Peng.,Ren, Di.,Shen, Min.,...&Liu, Yong.(2020).Virus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes.World Journal of Clinical Cases,8(24).
MLA	Chen, Pei-Fen,et al."Virus load and virus shedding of SARS-CoV-2 and their impact on patient outcomes".World Journal of Clinical Cases 8.24(2020).