Vitamin A and Its Multi-Effects on Pancreas: Recent Advances and Prospects

Zhou, Yunting1; Wang, Huiying1; Zhou, Junming2; Qiu, Shanhu3,4; Cai, Tingting1; Li, Huiqin1; Shen, Ziyang1; Hu, Yun1; Ding, Bo1; Luo, Menghui1; Huang, Rong1; Yan, Rengna1; Xu, Wei5; He, Cong6; Zhang, Yumin3; Li, Fengfei1; Sun, Zilin3; Ma, Jianhua1

2021-02-18

10.3389/fendo.2021.620941

Frontiers in Endocrinology   影响因子和分区

1664-2392

Vitamin A (VA), which is stored in several forms in most tissues, is required to maintain metabolite homeostasis and other processes, including the visual cycle, energy balance, epithelial cell integrity, and infection resistance. In recent years, VA molecules, also known as retinoids, have been extensively explored and used in the treatment of skin disorders and immune-related tumors. To date, several observational and interventional studies have explored the relationship between VA status and the pathogenesis of diabetes. In particular, VA micronutrients have been shown to regulate pancreatic development, beta-cell function, pancreatic innate immune responses, and pancreatic stellate cells phenotypes through multiple mechanisms. However, there are still many problems to be proven or resolved. In this review, we summarize and discuss recent and available evidence on VA biological metabolism in the pancreas. Analysis of the effects of VA on metabolism in the pancreas will contribute to our understanding of the supportive physiological roles of VA in pancreas protection.

vitamin A diabetes pancreas development function immune response pancreatic stellate cells

SCI

英语

其他

National Nature Science Foundation of China[NSFC-81870563]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000625133900001

FRONTIERS MEDIA SA

Web of Science

1.Nanjing Med Univ, Nanjing Hosp 1, Dept Endocrinol, Nanjing, Peoples R China
2.Nanjing Univ, Med Sch, Jinling Hosp, Dept Cadre Gastroenterol, Nanjing, Peoples R China
3.Southeast Univ, Sch Med, Zhongda Hosp, Dept Endocrinol,Inst Diabet, Nanjing, Peoples R China
4.Southern Univ Sci & Technol, Jinan Univ, Clin Med Coll 2,Affiliated Hosp 1, Dept Endocrinol,Shenzhen Peoples Hosp, Shenzhen, Peoples R China
5.Nanjing Med Univ, Xuzhou Clin Sch, Xuzhou Inst Med Sci, Dept Endocrinol,Xuzhou Cent Hosp, Xuzhou, Jiangsu, Peoples R China
6.Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing, Peoples R China

Zhou, Yunting,Wang, Huiying,Zhou, Junming,et al. Vitamin A and Its Multi-Effects on Pancreas: Recent Advances and Prospects[J]. Frontiers in Endocrinology,2021,12.

Zhou, Yunting.,Wang, Huiying.,Zhou, Junming.,Qiu, Shanhu.,Cai, Tingting.,...&Ma, Jianhua.(2021).Vitamin A and Its Multi-Effects on Pancreas: Recent Advances and Prospects.Frontiers in Endocrinology,12.

Zhou, Yunting,et al."Vitamin A and Its Multi-Effects on Pancreas: Recent Advances and Prospects".Frontiers in Endocrinology 12(2021).