UBE2R2-AS1 Inhibits Xenograft Growth in Nude Mice and Correlates with a Positive Prognosis in Glioma

Xu, Wu1,3; Che, Dan-dan2; Chen, Liang3; Lv, Sheng-qing4; Su, Jun1; Tan, Jun1; Liu, Qing1; Pan, Ya-wen5

2021-02-01

10.1007/s12031-021-01793-y

JOURNAL OF MOLECULAR NEUROSCIENCE   影响因子和分区

0895-8696

1559-1166

Our previous study showed that the lncRNA UBE2R2-AS1 inhibits the growth and invasion of glioma cells and promotes apoptosis through the miR-877-3p/TLR4 pathway. In this study, it was further found that the expression of UBE2R2-AS1 in glioma tissues was decreased significantly, and gradually decreased with increasing clinical stage. Chi-square analysis showed that the expression of UBE2R2-AS1 was significantly correlated with the WHO stage of tumor and epilepsy. Using Kaplan-Meier univariate survival analysis, it was found that the expression of UBE2R2-AS1 correlated positively with the overall survival of patients with glioma, while multiple Cox regression analysis showed that the expression of UBE2R2-AS1 correlated positively with the overall survival of patients with glioma as a protective factor for glioma prognosis. The analysis of data from TCGA also showed that patients with high UBE2R2-AS1 levels or low miR-877-3p expression were more likely to have good survival outcomes. Further construction of a glioma xenograft model in nude mice showed that UBE2R2-AS1 overexpression inhibited the growth of tumors, and the inhibition of miR-877-3p expression had a similar effect. Simultaneous UBE2R2-AS1 overexpression and miR-877-3p inhibition further decreased the growth rate of tumors in nude mice. Taken together, the results of our study suggest that UBE2R2-AS1 is an important tumor suppressor gene in glioma, which may be a good marker and treatment target for the clinical detection of glioma.

Glioma lncRNA miR-877-3p Prognosis

SCI

英语

其他

Biochemistry & Molecular Biology ; Neurosciences & Neurology

Biochemistry & Molecular Biology ; Neurosciences

WOS:000613983200001

HUMANA PRESS INC

NEUROSCIENCE & BEHAVIOR

Web of Science

1.Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 2, Peoples Hosp Shenzhen 3, Dept Intens Care Unit, Shenzhen 518100, Guangdong, Peoples R China
3.Jiujiang Univ, Affiliated Hosp, Dept Neurosurg, Jiujiang 332000, Jiangxi, Peoples R China
4.Third Mil Med Univ, Xinqiao Hosp, Dept Neurosurg, Chongqing 400037, Peoples R China
5.Lanzhou Univ, Hosp 2, Dept Neurosurg, Lanzhou 730030, Gansu, Peoples R China

Xu, Wu,Che, Dan-dan,Chen, Liang,et al. UBE2R2-AS1 Inhibits Xenograft Growth in Nude Mice and Correlates with a Positive Prognosis in Glioma[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2021.

Xu, Wu.,Che, Dan-dan.,Chen, Liang.,Lv, Sheng-qing.,Su, Jun.,...&Pan, Ya-wen.(2021).UBE2R2-AS1 Inhibits Xenograft Growth in Nude Mice and Correlates with a Positive Prognosis in Glioma.JOURNAL OF MOLECULAR NEUROSCIENCE.

Xu, Wu,et al."UBE2R2-AS1 Inhibits Xenograft Growth in Nude Mice and Correlates with a Positive Prognosis in Glioma".JOURNAL OF MOLECULAR NEUROSCIENCE (2021).