Role of peroxisome proliferator-activated receptors in osteoarthritis

Huang, Gang1,2; Jiang, Wei3,4; Xie, Weiyong1; Lu, Wei2,5,6,7; Zhu, Weimin2,5,6,7; Deng, Zhenhan2,5,6,7

2021-02-01

10.3892/mmr.2020.11798

Molecular Medicine Reports   影响因子和分区

1791-2997

1791-3004

Osteoarthritis (OA) is the most common form of arthritis, for which treatment options are not always satisfactory, since complete cure for OA is not yet possible. A better understanding of OA pathogenesis is thus important. The peroxisome proliferator-activated receptor (PPAR) plays a major regulatory role in lipid metabolism and energy homeostasis. This review article aimed to discuss the biological function of PPARs, and their role in regulating OA progression, as well as the therapeutic aspect of PPARs in OA. Studies indicate that PPARs regulate articular cartilage homeostasis through the modulation of various signaling pathways, and reduce the inflammatory responses in human OA cartilage. Furthermore, the deficiency of PPARs in the articular cartilage might be responsible for the acceleration of severe OA by increasing catabolic activity and suppression of chondroprotection. Therapeutic applications of PPAR-agonists can thus reduce the development of cartilage lesions by inhibiting the synthesis of various catabolic and inflammatory factors involved in the pathogenesis of OA. PPARs are thus important proteins in OA regulation, which may have significant importance in OA therapeutics.

osteoarthritis peroxisome proliferator-activated receptor chondroprotection inflammatory responses peroxisome proliferator-activated receptor agonists

SCI

英语

其他

National Natural Science Foundation of China[81902303] ; Guangdong Basic and Applied Basic Research Foundation[2020A151501048] ; Shenzhen Science and Technology Project["JCYJ20190806164216661","GJHZ20180416164801042","JCYJ20180305124912336"] ; Clinical Research Project of Shezhen Second People's Hospital[20203357028]

Oncology ; Research & Experimental Medicine

Oncology ; Medicine, Research & Experimental

WOS:000607952200001

SPANDIDOS PUBL LTD

Web of Science

1.Orthoped Hosp Longgang, Dept Sports Med, Shenzhen 518116, Guangdong, Peoples R China
2.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Hlth Sci Ctr,Dept Sports Med, 3002 Sungang West Rd, Shenzhen 518035, Guangdong, Peoples R China
3.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Bone & Joint Dept, Shenzhen 518020, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
5.Shenzhen Univ, Sch Med, Shenzhen 518035, Guangdong, Peoples R China
6.Guangzhou Med Univ, Sch Med, Guangzhou 510182, Guangdong, Peoples R China
7.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Key Lab Tissue Engn Shenzhen,Hlth Sci Ctr, Shenzhen 518035, Guangdong, Peoples R China

Huang, Gang,Jiang, Wei,Xie, Weiyong,et al. Role of peroxisome proliferator-activated receptors in osteoarthritis[J]. Molecular Medicine Reports,2021,23(2).

Huang, Gang,Jiang, Wei,Xie, Weiyong,Lu, Wei,Zhu, Weimin,&Deng, Zhenhan.(2021).Role of peroxisome proliferator-activated receptors in osteoarthritis.Molecular Medicine Reports,23(2).

Huang, Gang,et al."Role of peroxisome proliferator-activated receptors in osteoarthritis".Molecular Medicine Reports 23.2(2021).