Integrative analysis of the characteristics of lipid metabolism-related genes as prognostic prediction markers for hepatocellular carcinoma

Zhu, P.1; Li, F-F2; Zeng, J.5; Tang, D-G3,4; Chen, W-B3,4; Guo, C-C1

2021

10.26355/eurrev_202101_24355

European Review for Medical and Pharmacological Sciences   影响因子和分区

1128-3602

["OBJECTIVE: Dysregulated lipid metabolism has been reported in the progression of hepatocellular carcinoma (HCC). In the present study. we investigated the molecular characteristics of lipid-metabolism-related genes (IMRGs) as prognostic markers for HCC.","MATERIALS AND METHODS: Multi-dimensional bioinformatics analyses were performed to comprehensively analyze IMRGs, and to construct prognostic prediction signatures.","RESULTS: Data of 770 HCC patients and their corresponding 776 IMRGs were downloaded from three databases. Patients were classified into 2 molecular clusters that were associated with overall survival, clinical characteristics, and immune cells. The biological functions of the IMRGs differentially expressed between the 2 clusters were associated with tumor-related metabolic pathways. A 6 IMRG signature (6-IS), consisting of FMO3, SLC11A1, RNF10, KCNH2, ME1, and ZIC2, was established as an independent prognostic factor for HCC. The performance of the signature of 6-IS prognostic was verified in a validation set and compared to an external data set. It was revealed that the 6-IS could effectively predict the prognosis of patients with HCC.","CONCLUSIONS: This study provides new insights into the role of IMRGs in the pathogenesis of HCC, and presents a novel signature (6-IS) to predict the prognosis of HCC."]

Lipid metabolism Gene Prognosis Hepatocellular carcinoma Bioinformatics analysis

SCI

英语

通讯

Shenzhen Science and Technology Innovation Commission[JCYJ20170307153704628] ; Health Scientific Research Project of Pingshan District, Shenzhen City[201714]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000616978100021

VERDUCI PUBLISHER

Web of Science

1.Shenzhen Pingshan Peoples Hosp, Cent Lab, Shenzhen, Peoples R China
2.Jinan Univ, Affiliated Hosp 1, 1 Class Ward 2, Guangzhou, Peoples R China
3.Jinan Univ, Dept Clin Med Res Ctr, Clin Med Coll 2, Guangzhou, Peoples R China
4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen, Peoples R China
5.Univ Chinese Acad Sci, Shenzhen Hosp, Ctr Med Genet & Mol Diag, Shenzhen, Peoples R China

Zhu, P.,Li, F-F,Zeng, J.,et al. Integrative analysis of the characteristics of lipid metabolism-related genes as prognostic prediction markers for hepatocellular carcinoma[J]. European Review for Medical and Pharmacological Sciences,2021,25(1).

Zhu, P.,Li, F-F,Zeng, J.,Tang, D-G,Chen, W-B,&Guo, C-C.(2021).Integrative analysis of the characteristics of lipid metabolism-related genes as prognostic prediction markers for hepatocellular carcinoma.European Review for Medical and Pharmacological Sciences,25(1).

Zhu, P.,et al."Integrative analysis of the characteristics of lipid metabolism-related genes as prognostic prediction markers for hepatocellular carcinoma".European Review for Medical and Pharmacological Sciences 25.1(2021).