Accumulation of LOX-1(+) PMN-MDSCs in nasopharyngeal carcinoma survivors with chronic hepatitis B might permit immune tolerance to epstein-barr virus and relate to tumor recurrence

Li, Xing1,2,3; Li, Jin-Long1,4; Jiang, Nan5,6; Chen, Jie2,3; Liang, Zi-Ming5,6; Zhao, Zhen-Lin1; Xing, Yan-Fang7

2021-01-15

Aging-US   影响因子和分区

1945-4589

Chronic hepatitis B (CHB) has been reported to be associated with impaired prognosis for patients with nasopharyngeal carcinoma (NPC). However, the latent mechanism is unclear. Polymorphonuclear myeloid derived suppressor cells (PMN-MDSCs) induce immune suppression in CHB and promote the development of hepatocellular carcinoma. Lectin-type oxidized LDL receptor-1 (LOX-1) was recently identified as a specific marker for PMN-MSDC. We found NPC survivors with CHB had high levels of LOX-1(+) PMN-MDSCs. LOX-1+PMNMDSCs significantly reduced T cell proliferation and activation. Endoplasmic reticulum stress was induced in LOX-1(+) PMN-MDSCs. In addition, LOX-1(+) PMN-MDSCs increased their expression of NOX2, a key reactive oxygen species (ROS)-related genes, and levels of ROS illustrated by the DCFDA test. The ROS inhibitor N-acetylcysteine abrogated the suppression of LOX-1(+) PMN-MDSCs on T cell activation. The EBV DNA-positivity rate was higher in NPC survivors with CHB than in NPC patients without CHB. Those presenting with positive EBV DNA displayed higher LOX-1(+) PMN-MDSC levels. LOX-1(+) PMN-MDSCs suppressed the CD8(+) T cell response against EBV. This study revealed LOX-1(+) PMN-MDSC accumulation and activation in NPC survivors with CHB. LOX-1(+) PMN-MDSCs might suppress the host immune response to EBV through ER stress/ROS pathway. These results explained the association of CHB with unfavorable NPC prognosis.

Epstein-Barr virus lectin-type oxidized LDL receptor-1 polymorphonuclear myeloid-derived suppressor cell nasopharyngeal carcinoma chronic hepatitis B

SCI

英语

其他

Shenzhen science and technology project["JCYJ20180305124227251","JCYJ20180305164655077"] ; National Natural Science Foundation of China[81972677,81871999,81700645] ; Natural Science Foundation of Guangdong["2019A1515012198","2019A1515011187"] ; Guangzhou Science and Technology Project[201904010461] ; Fundamental Research Funds for the Central Universities[19ykpy17] ; Guangdong High-Level Personnel of Special Support Program Outstanding young scholar in science and technology innovation[2019TQ05Y266]

Cell Biology ; Geriatrics & Gerontology

Cell Biology ; Geriatrics & Gerontology

WOS:000611163500008

IMPACT JOURNALS LLC

Web of Science

1.Shenzhen Ruipuxun Acad Stem Cell & Regenerat Med, Shenzhen 518118, Peoples R China
2.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Med Oncol, Guangzhou 510630, Peoples R China
3.Sun Yat Sen Univ, Affiliated Hosp 3, Guangdong Key Lab Liver Dis Res, Guangzhou 510630, Peoples R China
4.Southern Med Univ, Sch Lab Med & Biotechnol, Inst Biotherapy, Guangzhou 510515, Peoples R China
5.Southern Univ Sci & Technol, Affiliated Hosp 2, Dept Transplantat, Shenzhen 510623, Peoples R China
6.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Shenzhen 510623, Peoples R China
7.Guangzhou Med Univ, Affiliated Hosp 3, Dept Nephrol, Guangzhou 510150, Peoples R China

Li, Xing,Li, Jin-Long,Jiang, Nan,et al. Accumulation of LOX-1(+) PMN-MDSCs in nasopharyngeal carcinoma survivors with chronic hepatitis B might permit immune tolerance to epstein-barr virus and relate to tumor recurrence[J]. Aging-US,2021,13(1).

Li, Xing.,Li, Jin-Long.,Jiang, Nan.,Chen, Jie.,Liang, Zi-Ming.,...&Xing, Yan-Fang.(2021).Accumulation of LOX-1(+) PMN-MDSCs in nasopharyngeal carcinoma survivors with chronic hepatitis B might permit immune tolerance to epstein-barr virus and relate to tumor recurrence.Aging-US,13(1).

Li, Xing,et al."Accumulation of LOX-1(+) PMN-MDSCs in nasopharyngeal carcinoma survivors with chronic hepatitis B might permit immune tolerance to epstein-barr virus and relate to tumor recurrence".Aging-US 13.1(2021).