Smart nano-micro platforms for ophthalmological applications: The state-of-the-art and future perspectives

Lyu, Qinghua1,2; Peng, Ling2; Hong, Xiangqian1,2; Fan, Taojian2; Li, Jingying3; Cui, Yubo4,5; Zhang, Han2; Zhao, Jun1,4,5

2021-03-01

10.1016/j.biomaterials.2021.120682

BIOMATERIALS   影响因子和分区

0142-9612

1878-5905

Smart nano-micro platforms have been extensively applied for diverse biomedical applications, mostly focusing on cancer therapy. In comparison with conventional nanotechnology, the smart nano-micro matrix can exhibit specific response to exogenous or endogenous triggers, and thus can achieve multiple functions e.g. site-specific drug delivery, bio-imaging and detection of bio-molecules. These intriguing techniques have expanded into ophthalmology in recent years, yet few works have been summarized in this field. In this work, we provide the state-of-the-art of diverse nano-micro platforms based on both the conventional materials (e.g. natural or synthetic polymers, lipid nanomaterials, metal and metal oxide nanoparticles) and emerging nanomaterials (e.g. upconversion nanoparticles, quantum dots and carbon materials) in ophthalmology, with some smart nano/micro platformers highlighted. The common ocular diseases studied in the field of nano-micro systems are firstly introduced, and their therapeutic method and the related drawback in clinic treatment are presented. The recent progress of different materials for diverse ocular applications is then demonstrated, with the representative nanoand micro-systems highlighted in detail. At last, an in-depth discussion on the clinical translation challenges faced in this field and the future direction are provided. This review would allow the researchers to design more smart nanomedicines in a more rational manner for specific ophthalmology applications.

Smart nano-micro platform Drug delivery Stimuli-response Ophthalmology

SCI ; EI

英语

通讯

State Key Research Development Program of China[2019YFB2203503] ; Innovation Team Project of Department of Education of Guangdong Province[2018KCXTD026] ; Science, Technology, and Innovation Commission of Shenzhen Municipality["JCYJ20180228164400218","GJHZ20180420180937076"] ; Sanming Project of Medicine in Shenzhen[SZSM201812090] ; China Postdoctoral Science Foundation[2020M672784]

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000621600100004

ELSEVIER SCI LTD

MATERIALS SCIENCE

Web of Science

1.Shenzhen Univ, Shenzhen Eye Hosp, Sch Ophthalmol & Optometry, Shenzhen 518040, Peoples R China
2.Shenzhen Univ, Inst Microscale Optoelect,Collaborat Innovat Ctr, Key Lab Optoelect Devices & Syst,Minist Educ & Gu, Coll Phys & Optoelect Engn,Shenzhen Key Lab Micro, Shenzhen 518060, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Ophthalmol, Shenzhen 518000, Peoples R China
4.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Ophthalmol, Shenzhen 518020, Peoples R China
5.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China

Lyu, Qinghua,Peng, Ling,Hong, Xiangqian,et al. Smart nano-micro platforms for ophthalmological applications: The state-of-the-art and future perspectives[J]. BIOMATERIALS,2021,270.

Lyu, Qinghua.,Peng, Ling.,Hong, Xiangqian.,Fan, Taojian.,Li, Jingying.,...&Zhao, Jun.(2021).Smart nano-micro platforms for ophthalmological applications: The state-of-the-art and future perspectives.BIOMATERIALS,270.

Lyu, Qinghua,et al."Smart nano-micro platforms for ophthalmological applications: The state-of-the-art and future perspectives".BIOMATERIALS 270(2021).