A novel hypoxia gene signature indicates prognosis and immune microenvironments characters in patients with hepatocellular carcinoma

Zhang, Qiangnu1,2; Qiao, Lijun1,2; Liao, Juan3,4; Liu, Quan1,2; Liu, Pengyu5; Liu, Liping1,6

2021-02-01

10.1111/jcmm.16249

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE   影响因子和分区

1582-1838

1582-4934

Due to the lack of a suitable gene signature, it is difficult to assess the hypoxic exposure of HCC tissues. The clinical value of assessing hypoxia in HCC is short of tissue-level evidence. We tried to establish a robust and HCC-suitable hypoxia signature using microarray analysis and a robust rank aggregation algorithm. Based on the hypoxia signature, we obtained a hypoxia-associated HCC subtypes system using unsupervised hierarchical clustering and a hypoxia score system was provided using gene set variation analysis. A novel signature containing 21 stable hypoxia-related genes was constructed to effectively indicate the exposure of hypoxia in HCC tissues. The signature was validated by qRT-PCR and compared with other published hypoxia signatures in multiple large-size HCC cohorts. The subtype of HCC derived from this signature had different prognosis and other clinical characteristics. The hypoxia score obtained from the signature could be used to indicate clinical characteristics and predict prognoses of HCC patients. Moreover, we reveal a landscape of immune microenvironments in patients with different hypoxia score. In conclusion, we identified a novel HCC-suitable 21-gene hypoxia signature that could be used to estimate the hypoxia exposure in HCC tissues and indicated prognosis and a series of important clinical features in HCCs. It may enable the development of personalized counselling or treatment strategies for HCC patients with different levels of hypoxia exposure.

gene signature HCC hypoxia microenvironment prognosis

SCI

英语

通讯

Science and Technology Innovation Commission of Shenzhen[KQJSCX20180321164801762] ; International Cooperation in Science and Technology/Research and Development Program of Sichuan Province[20GJHZ0231]

Cell Biology ; Research & Experimental Medicine

Cell Biology ; Medicine, Research & Experimental

WOS:000620211000001

WILEY

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Hepatobiliary & Pancreas Surg, Shenzhen, Peoples R China
2.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou, Peoples R China
3.Sichuan Univ, West China Sch Publ Hlth, Dept Gastroenterol, Chengdu, Peoples R China
4.Sichuan Univ, West China Hosp 4, Chengdu, Peoples R China
5.Erasmus MC Univ, Med Ctr, Dept Gastroenterol & Hepatol, Rotterdam, NY USA
6.Southern Univ Sci & Technol, Affiliated Hosp 1, Dept Hepatobiliary & Pancreas Surg, Shenzhen 518020, Guangdong, Peoples R China

Zhang, Qiangnu,Qiao, Lijun,Liao, Juan,et al. A novel hypoxia gene signature indicates prognosis and immune microenvironments characters in patients with hepatocellular carcinoma[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2021,25(8).

Zhang, Qiangnu,Qiao, Lijun,Liao, Juan,Liu, Quan,Liu, Pengyu,&Liu, Liping.(2021).A novel hypoxia gene signature indicates prognosis and immune microenvironments characters in patients with hepatocellular carcinoma.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,25(8).

Zhang, Qiangnu,et al."A novel hypoxia gene signature indicates prognosis and immune microenvironments characters in patients with hepatocellular carcinoma".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 25.8(2021).