Exploring and exploiting plant cyclic peptides for drug discovery and development

Zhang, Jingjing1,2,3; Yuan, Jimin1,2; Li, Zhijie1,2; Fu, Chunjin1,2; Xu, Menglong4; Yang, Jing1,2; Jiang, Xin1,2; Zhou, Boping2,5; Ye, Xiufeng2,6; Xu, Chengchao1,2,4

2021-02-01

10.1002/med.21792

MEDICINAL RESEARCH REVIEWS   影响因子和分区

0198-6325

1098-1128

Ever since the discovery of insulin, natural peptides have become an important resource for therapeutic development. Decades of research has led to the discovery of a long list of peptide drugs with broad applications in clinics, from antibiotics to hypertension treatment to pain management. Many of these US FDA-approved peptide drugs are derived from microorganisms and animals. By contrast, the great potential of plant cyclic peptides as therapeutics remains largely unexplored. These macrocyclic peptides typically have rigid structures, good bioavailability and membrane permeability, making them appealing candidates for drug development and engineering. In this review, we introduce the three major classes of plant cyclic peptides and summarize their potential medical applications. We discuss how we can leverage the genome information of many different plants to quickly search for new cyclic peptides and how we can take advantage of the insights gained from their biosynthetic pathways to transform the process of production and drug development. These recent developments have provided a new angle for exploring and exploiting plant cyclic peptides, and we believe that many more peptide drugs derived from plants are about to come.

cyclotides orbitides peptide scaffold peptide‐ based drug SFTI‐ 1

SCI

英语

通讯

National Natural Science Foundation of China[32000536,32000026] ; Shenzhen Science and Technology Innovation Commission[JCYJ20190807145209306] ; Shenzhen Economic and Information Committee "Innovation Chain and Industry Chain" integration special support plan project[20180225112449943]

Pharmacology & Pharmacy

Chemistry, Medicinal ; Pharmacology & Pharmacy

WOS:000619128900001

WILEY

PHARMACOLOGY & TOXICOLOGY

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Geriatr Med, Shenzhen, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou, Guangdong, Peoples R China
4.Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA
5.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Infect Dis, Shenzhen 518020, Guangdong, Peoples R China
6.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China

Zhang, Jingjing,Yuan, Jimin,Li, Zhijie,et al. Exploring and exploiting plant cyclic peptides for drug discovery and development[J]. MEDICINAL RESEARCH REVIEWS,2021.

Zhang, Jingjing.,Yuan, Jimin.,Li, Zhijie.,Fu, Chunjin.,Xu, Menglong.,...&Xu, Chengchao.(2021).Exploring and exploiting plant cyclic peptides for drug discovery and development.MEDICINAL RESEARCH REVIEWS.

Zhang, Jingjing,et al."Exploring and exploiting plant cyclic peptides for drug discovery and development".MEDICINAL RESEARCH REVIEWS (2021).