Optical tweezers beyond refractive index mismatch using highly doped upconversion nanoparticles

Shan, Xuchen1; Wang, Fan1,2; Wang, Dejiang1; Wen, Shihui1; Chen, Chaohao1; Di, Xiangjun1; Nie, Peng1,3; Liao, Jiayan1; Liu, Yongtao1; Ding, Lei1; Reece, Peter J.4; Jin, Dayong1,5

2021-02-01

10.1038/s41565-021-00852-0

Nature Nanotechnology   影响因子和分区

1748-3387

1748-3395

Optical tweezers are widely used in materials assembly(1), characterization(2), biomechanical force sensing(3,4) and the in vivo manipulation of cells(5) and organs(6). The trapping force has primarily been generated through the refractive index mismatch between a trapped object and its surrounding medium. This poses a fundamental challenge for the optical trapping of low-refractive-index nanoscale objects, including nanoparticles and intracellular organelles. Here, we report a technology that employs a resonance effect to enhance the permittivity and polarizability of nanocrystals, leading to enhanced optical trapping forces by orders of magnitude. This effectively bypasses the requirement of refractive index mismatch at the nanoscale. We show that under resonance conditions, highly doping lanthanide ions in NaYF4 nanocrystals makes the real part of the Clausius-Mossotti factor approach its asymptotic limit, thereby achieving a maximum optical trap stiffness of 0.086 pN mu m(-1) mW(-1) for 23.3-nm-radius low-refractive-index (1.46) nanoparticles, that is, more than 30 times stronger than the reported value for gold nanoparticles of the same size. Our results suggest a new potential of lanthanide doping for the optical control of the refractive index of nanomaterials, developing the optical force tag for the intracellular manipulation of organelles and integrating optical tweezers with temperature sensing and laser cooling(7) capabilities.

SCI ; EI

英语

NI论文

通讯

UTS Chancellor's Postdoctoral Research Fellowship[PRO18-6128] ; Australian Research Council (ARC) DECRA fellowship[DE200100074] ; ARC Discovery Project[DP190101058] ; National Natural Science Foundation of China (NSFC)[61729501] ; Major International (Regional) Joint Research Project of the NSFC[51720105015] ; Science and Technology Innovation Commission of Shenzhen[KQTD20170810110913065] ; Australia-China Science and Research Fund Joint Research Centre for Point-of-Care Testing["ACSRF658277","SQ2017YFGH001190"] ; China Scholarship Council["201708200004l",201706170027,201706170028,201607950009,201508530231,201607950010,201809370076]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000619406100001

NATURE RESEARCH

20210809972897

Fluorine compounds ; Gold nanoparticles ; Laser cooling ; Molecular biology ; Nanocrystals ; Nanoparticles ; Optical tweezers ; Rare earth elements ; Sodium compounds ; Yttrium compounds

Biology:461.9 ; Rare Earth Metals:547.2 ; Light/Optics:741.1 ; Laser Applications:744.9 ; Nanotechnology:761 ; Solid State Physics:933

Web of Science

1.Univ Technol Sydney, Fac Sci, Inst Biomed Mat & Devices IBMD, Sydney, NSW, Australia
2.Univ Technol Sydney, Sch Elect & Data Engn, Fac Engn & Informat Technol, Sydney, NSW, Australia
3.Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou, Peoples R China
4.Univ New South Wales, Sch Phys, Sydney, NSW, Australia
5.Southern Univ Sci & Technol, UTS SUStech Joint Res Ctr Biomed Mat & Devices, Dept Biomed Engn, Shenzhen, Peoples R China

Shan, Xuchen,Wang, Fan,Wang, Dejiang,et al. Optical tweezers beyond refractive index mismatch using highly doped upconversion nanoparticles[J]. Nature Nanotechnology,2021,16:531-537.

Shan, Xuchen.,Wang, Fan.,Wang, Dejiang.,Wen, Shihui.,Chen, Chaohao.,...&Jin, Dayong.(2021).Optical tweezers beyond refractive index mismatch using highly doped upconversion nanoparticles.Nature Nanotechnology,16,531-537.

Shan, Xuchen,et al."Optical tweezers beyond refractive index mismatch using highly doped upconversion nanoparticles".Nature Nanotechnology 16(2021):531-537.