Application of single-cell RNA sequencing in embryonic development

Yu Shangguan1,2,3; Li, Chunhong1,2,3; Lin, Hua2; Ou, Minglin2; Tang, Donge2,3; Dai, Yong2,3; Yan, Qiang1,2

2020-11-01

10.1016/j.ygeno.2020.08.007

GENOMICS   影响因子和分区

0888-7543

1089-8646

Embryonic development is a complex process that is regulated by a series of precise cellular behaviours. The limited number of cells in the early stages of embryonic development represents a challenge for studying early gene regulation and maintaining cell sternness. Single-cell sequencing is a new technology for high-throughput sequencing analysis at the single-cell level that not only reflects the heterogeneity between cells but also reveals gene expression characteristics in different cells from limited samples. Currently, the widespread application of single-cell RNA sequencing technology is gradually changing our understanding of disease pathogenesis. This article reviews the application of single-cell RNA sequencing in embryonic development in recent years and provides innovative ideas for research on embryonic development and the treatment of diseases related to embryonic development.

Single-cell RNA sequencing Embryonic development Cellular heterogeneity

SCI

英语

通讯

Science and Technology Planning Project of Guangdong Province, China[2017B020209001] ; Natural Science Foundation of Guangdong Province, China[2017A030310629] ; Guangxi Zhuang Autonomous Region Natural Science Foundation[2017gxnsfaa198185] ; Key Laboratory Construction Project Plan of Guangxi Zhuang Autonomous Region[17259-57]

Biotechnology & Applied Microbiology ; Genetics & Heredity

Biotechnology & Applied Microbiology ; Genetics & Heredity

WOS:000600733400004

ACADEMIC PRESS INC ELSEVIER SCIENCE

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Guangxi Normal Univ, Coll Life Sci, Guilin 541004, Guangxi, Peoples R China
2.Guilin 924st Hosp, Organ Transplant Ctr, Guangxi Key Lab Metab Dis Res, Guilin 541002, Guangxi, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Clin Med Res Ctr, Jinan Univ,Clin Med Coll 2,Affiliated Hosp 1, Shenzhen 518020, Peoples R China

Yu Shangguan,Li, Chunhong,Lin, Hua,et al. Application of single-cell RNA sequencing in embryonic development[J]. GENOMICS,2020,112(6).

Yu Shangguan.,Li, Chunhong.,Lin, Hua.,Ou, Minglin.,Tang, Donge.,...&Yan, Qiang.(2020).Application of single-cell RNA sequencing in embryonic development.GENOMICS,112(6).

Yu Shangguan,et al."Application of single-cell RNA sequencing in embryonic development".GENOMICS 112.6(2020).