Oral Administration of Starting Materials for In Vivo Synthesis of Antibacterial Gold Nanoparticles for Curing Remote Infections

Wang, Le1,2; Yang, Junchuan3; Li, Sixiang2; Li, Qizhen2; Liu, Shaoqin1; Zheng, Wenfu3; Jiang, Xingyu1,2

2021-01-27

10.1021/acs.nanolett.0c04578

NANO LETTERS   影响因子和分区

1530-6984

1530-6992

Oral administration is a facile and safe way for medication. However, most of the reported nanomedicines could not be taken orally, partially due to their unsatisfied stability, poor absorbance, or toxicity in the gastrointestinal tract. Here, we demonstrate that we could robustly synthesize gold nanoparticles (GNPs) in vivo by orally administering two starting materials, tetrachloroauric acid and aminophenyl boronic acid (ABA). The ABA-activated GNPs (A-GNPs) synthesized in vivo could be absorbed by the gastrointestinal tract and reach the remote infection lesions such as peritonitis caused by multidrug resistant (MDR) bacteria in mice. The A-GNPs exhibit excellent antibacterial efficacy (MIC, 3 mu g/mL), long half-life (16-17 h), effective clearance (residual concentration is near 0 within 72 h), and high biosafety (safe dose/effective dose, 8 times). Our study is a pioneering attempt for synthesizing and taking nanomedicines orally just like preparing and drinking a cocktail.

Gold nanoparticles Antibacterial Oral administration In vivo synthesis Biosafety

SCI ; EI

英语

NI论文

通讯

Shenzhen Science and Technology Program[KQTD20190929172743294] ; National Natural Science Foundation of China[21535001,81730051,81673039,32071390] ; National Key R&D Program of China[2018YFA0902600] ; Chinese Academy of Sciences["QYZDJ-SSW-SLH039","121D11KYSB20170026"] ; Shenzhen Bay Laboratory[SZBL2019062801004] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000614066800033

AMER CHEMICAL SOC

20210509867087

Fiber optic sensors ; Gold nanoparticles ; Mammals ; Metal nanoparticles

Fiber Optics:741.1.2 ; Nanotechnology:761 ; Chemical Reactions:802.2

MATERIALS SCIENCE

Web of Science

1.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China
2.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
3.Natl Ctr NanoSci & Technol, GBA Natl Inst Nanotechnol Innovat, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

Wang, Le,Yang, Junchuan,Li, Sixiang,et al. Oral Administration of Starting Materials for In Vivo Synthesis of Antibacterial Gold Nanoparticles for Curing Remote Infections[J]. NANO LETTERS,2021,21(2):1124-1131.

Wang, Le.,Yang, Junchuan.,Li, Sixiang.,Li, Qizhen.,Liu, Shaoqin.,...&Jiang, Xingyu.(2021).Oral Administration of Starting Materials for In Vivo Synthesis of Antibacterial Gold Nanoparticles for Curing Remote Infections.NANO LETTERS,21(2),1124-1131.

Wang, Le,et al."Oral Administration of Starting Materials for In Vivo Synthesis of Antibacterial Gold Nanoparticles for Curing Remote Infections".NANO LETTERS 21.2(2021):1124-1131.