Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma

Yang, Ying3; Wang, Jin1,2; Xu, Shihai1,2; Shi, Fei1,2; Shan, Aijun1,2

2021

10.1515/tnsci-2021-0004

Translational Neuroscience   影响因子和分区

2081-3856

2081-6936

["Background - Calumenin (CALU) has been reported to be associated with invasiveness and metastasis in some malignancies. However, in glioma, the role of CALU remains unclear.","Methods - Clinical and transcriptome data of 998 glioma patients, including 301 from CGGA and 697 from TCGA dataset, were included. R language was used to perform statistical analyses.","Results - CALU expression was significantly upregulated in more malignant gliomas, including higher grade, IDH wildtype, mesenchymal, and classical subtype. Gene Ontology analysis revealed that CALU-correlated genes were mainly enriched in cell/biological adhesion, response to wounding, and extracellular matrix/structure organization, all of which were strongly correlated with the epithelial-mesenchymal transition (EMT) phenotype. GSEA further validated the profound involvement of CALU in EMT. Subsequent GSVA suggested that CALU was particularly correlated with three EMT signaling pathways, including TGF beta, PI3K/AKT, and hypoxia pathway. Furthermore, CALU played synergistically with EMT key markers, including N-cadherin, vimentin, snail, slug, and TWIST1. Survival and Cox regression analysis showed that higher CALU predicted worse survival, and the prognostic value was independent of WHO grade and age.","Conclusions - CALU was correlated with more malignant phenotypes in glioma. Moreover, CALU seemed to serve as a pro-EMT molecular target and could contribute to predict prognosis independently in glioma."]

calumenin glioma epithelial-mesenchymal transition

SCI

英语

通讯

Medical Scientific Research Foundation of Shenzhen Health Commission[szfz2018022] ; Shenzhen Science and Technology Innovation Foundation[JCYJ20190806150005453] ; Futian PublicWelfare Scientific ResearchProject[FTWS2020099]

Neurosciences & Neurology

Neurosciences

WOS:000617112600005

DE GRUYTER POLAND SP Z O O

Web of Science

1.Jinan Univ, Clin Med Coll 2, Dept Emergency, Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China
3.Futian Women & Children Hlth Inst, Dept Pediat, Shenzhen 518045, Peoples R China

Yang, Ying,Wang, Jin,Xu, Shihai,et al. Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma[J]. Translational Neuroscience,2021,12(1).

Yang, Ying,Wang, Jin,Xu, Shihai,Shi, Fei,&Shan, Aijun.(2021).Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma.Translational Neuroscience,12(1).

Yang, Ying,et al."Calumenin contributes to epithelial-mesenchymal transition and predicts poor survival in glioma".Translational Neuroscience 12.1(2021).