南方科技大学知识苑(SUSTech KC): Highly Chemo- and Enantioselective Rh-Catalyzed Hydrogenation of beta-Sulfonyl-alpha,beta-unsaturated Ketones: Access to Chiral gamma-Ketosulfones

题名	Highly Chemo- and Enantioselective Rh-Catalyzed Hydrogenation of beta-Sulfonyl-alpha,beta-unsaturated Ketones: Access to Chiral gamma-Ketosulfones
作者	Liu, Gang 1; Yin, Congcong2 ; Yang, Xuanliang 1; Li, Anqi 1; Wang, Minyan 4; Zhang, Xumu2 ; Dong, Xiu-Qin 1,3
通讯作者	Wang, Minyan; Zhang, Xumu; Dong, Xiu-Qin
发表日期	2021
DOI	10.1021/acs.orglett.0c03517
发表期刊	ORGANIC LETTERS 影响因子和分区
ISSN	1523-7060
EISSN	1523-7052
卷号	23 期号:1
摘要	Rh-catalyzed highly chemo- and enantioselective hydrogenation of beta-sulfonyl-alpha,beta-unsaturated ketones was first successfully developed. Remarkably, a variety of enantioenriched gamma-ketosulfones were generated in good to high yields with excellent chemo/enantioselectivities (82-99% yields, >99:1 chemoselectivity, 88 to >99% ee). Moreover, the gram-scale asymmetric hydrogenation was carried out smoothly in 97% yield and 97% ee. Preliminary DFT computations furnished a reasonable explanation for the high chemoselectivity and enantioselectivity.
相关链接	[来源记录]
收录类别	SCI ; IC ; CCR
语种	英语
重要成果	NI论文
学校署名	通讯
资助项目	National Natural Science Foundation[22071187] ; Natural Science Foundation of Jiangsu Province["BK20190213","BK20170632"] ; Shenzhen Science and Technology Innovation Committee[KQTD20150717103157174]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000606842300005
出版者	AMER CHEMICAL SOC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：16
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/221386
专题	理学院_化学系深圳格拉布斯研究院
作者单位	1.Wuhan Univ, Coll Chem & Mol Sci, Engn Res Ctr Organosilicon Cpds & Mat, Key Lab Biomed Polymers,Minist Educ, Wuhan 430072, Hubei, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China 3.Wuhan Univ, Suzhou Inst, Suzhou 215123, Jiangsu, Peoples R China 4.Nanjing Univ, State Key Lab Coordinat Chem, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China
通讯作者单位	化学系; 深圳格拉布斯研究院
推荐引用方式 GB/T 7714	Liu, Gang,Yin, Congcong,Yang, Xuanliang,et al. Highly Chemo- and Enantioselective Rh-Catalyzed Hydrogenation of beta-Sulfonyl-alpha,beta-unsaturated Ketones: Access to Chiral gamma-Ketosulfones[J]. ORGANIC LETTERS,2021,23(1).
APA	Liu, Gang.,Yin, Congcong.,Yang, Xuanliang.,Li, Anqi.,Wang, Minyan.,...&Dong, Xiu-Qin.(2021).Highly Chemo- and Enantioselective Rh-Catalyzed Hydrogenation of beta-Sulfonyl-alpha,beta-unsaturated Ketones: Access to Chiral gamma-Ketosulfones.ORGANIC LETTERS,23(1).
MLA	Liu, Gang,et al."Highly Chemo- and Enantioselective Rh-Catalyzed Hydrogenation of beta-Sulfonyl-alpha,beta-unsaturated Ketones: Access to Chiral gamma-Ketosulfones".ORGANIC LETTERS 23.1(2021).