Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics

Jia，Zhanrong1; Lv，Xuanhan1; Hou，Yue1; Wang，Kefeng2; Ren，Fuzeng3; Xu，Dingguo2; Wang，Qun4; Fan，Kelong5,6; Xie，Chaoming1; Lu，Xiong1

2021-09-01

10.1016/j.bioactmat.2021.01.033

Bioactive Materials   影响因子和分区

2452-199X

Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics; however, fabricating adhesive hydrogels with multiple functions remains a challenge. In this study, a mussel-inspired tannic acid chelated-Ag (TA-Ag) nanozyme with peroxidase (POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles (NPs) with TA. The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid. The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone, providing the hydrogels with long-term and repeatable adhesiveness, similar to the adhesion of mussels. The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network, thereby improving its mechanical properties and conductivity. Furthermore, the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag. Owing to these advantages, the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive, antibacterial, and implantable bioelectrode to detect bio-signals, and as a wound dressing to accelerate tissue regeneration while preventing infection. Therefore, this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis.

Adhesive hydrogel Antibacterial hydrogel Bioelectronics Conductive hydrogel Mussel-inspired nanozyme

SCI

英语

ESI高被引

其他

WOS:000662249100004

2-s2.0-85100738449

Scopus

1.Key Lab of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,610031,China
2.National Engineering Research Center for Biomaterials,Sichuan University,Chengdu,610064,China
3.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
4.College of Life Science and Biotechnology,Mianyang Teachers' College,Mianyang,621006,China
5.CAS Engineering Laboratory for Nanozyme,Key Laboratory of Protein and Peptide Pharmaceuticals,Institute of Biophysics,Chinese Academy of Sciences,Beijing,100101,China
6.Nanozyme Medical Center,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou,450001,China

Jia，Zhanrong,Lv，Xuanhan,Hou，Yue,et al. Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics[J]. Bioactive Materials,2021,6(9):2676-2687.

Jia，Zhanrong.,Lv，Xuanhan.,Hou，Yue.,Wang，Kefeng.,Ren，Fuzeng.,...&Lu，Xiong.(2021).Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics.Bioactive Materials,6(9),2676-2687.

Jia，Zhanrong,et al."Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics".Bioactive Materials 6.9(2021):2676-2687.