| 题名 | Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation |
| 作者 | |
| 通讯作者 | Worley，Paul F.; Xiao，Bo |
| 共同第一作者 | Yang，Wanchun; Pang，Dejiang |
| 发表日期 | 2021-03-22
|
| DOI | |
| 发表期刊 | |
| ISSN | 1534-5807
|
| EISSN | 1878-1551
|
| 卷号 | 56期号:6页码:811-825.e6 |
| 摘要 | Neuronal activity is coordinated with neuroenergetics. Yang et al. demonstrate that dynamic translocation of Rheb to mitochondrial matrix activates pyruvate dehydrogenase (PDH) independent of mTORC1 and mediates neuronal-activity-regulated mitochondrial metabolism. Their findings suggest a mechanism by which Rheb integrates PDH-dependent energy production and mTORC1-dependent energy consumption. |
| 关键词 | |
| 相关链接 | [Scopus记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI论文
|
| 学校署名 | 通讯
|
| 资助项目 | National Natural Science Foundation of China[31501155,31530042,31371484,81571195]
; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[2021SHIBS0002]
|
| WOS研究方向 | Cell Biology
; Developmental Biology
|
| WOS类目 | Cell Biology
; Developmental Biology
|
| WOS记录号 | WOS:000631681200010
|
| 出版者 | |
| ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
|
| Scopus记录号 | 2-s2.0-85102648998
|
| 来源库 | Scopus
|
| 引用统计 |
被引频次[WOS]：30
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/221577 |
| 专题 | 生命科学学院_生物系 生命科学学院 |
| 作者单位 | 1.Neuroscience & Metabolism Research,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,610041,China 2.Department of Biology,School of Life Sciences,Brain Research Center,Southern University of Science and Technology,Shenzhen Key Laboratory of Gene Regulation and Systems Biology,Shenzhen,518055,China 3.Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu,610041,China 4.The Solomon H. Snyder Department of Neuroscience,Johns Hopkins University School of Medicine,Baltimore,21205,United States |
| 通讯作者单位 | 生物系; 生命科学学院 |
| 推荐引用方式 GB/T 7714 |
Yang，Wanchun,Pang，Dejiang,Chen，Mina,et al. Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation[J]. DEVELOPMENTAL CELL,2021,56(6):811-825.e6.
|
| APA |
Yang，Wanchun.,Pang，Dejiang.,Chen，Mina.,Du，Chongyangzi.,Jia，Lanlan.,...&Xiao，Bo.(2021).Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.DEVELOPMENTAL CELL,56(6),811-825.e6.
|
| MLA |
Yang，Wanchun,et al."Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation".DEVELOPMENTAL CELL 56.6(2021):811-825.e6.
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| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| Rheb mediates neuron（1072KB） | -- | -- | 限制开放 | -- | ||
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