Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease

Tan，Xin1; Chen，Huaisheng2; Zhang，Min3,4; Zhao，Ying5; Jiang，Yichun2; Liu，Xueyan2; Huang，Wei3,4; Ma，Yingfei1

2021-02-26

10.3389/fcimb.2021.631585

Frontiers in Cellular and Infection Microbiology   影响因子和分区

2235-2988

2235-2988

Overuse of antibiotics in clinical medicine has contributed to the global spread of multidrug-resistant bacterial pathogens, including Acinetobacter baumannii. We present a case of an 88-year-old Chinese man who developed hospital-acquired pneumonia caused by carbapenem-resistant A. baumannii (CRAB). A personalized lytic pathogen-specific single-phage preparation was nebulized to the patient continuously for 16 days in combination with tigecycline and polymyxin E. The treatment was well tolerated and resulted in clearance of the pathogen and clinical improvement of the patient’s lung function.

carbapenem-resistant Acinetobacter baumannii endotoxin lung infection personalized phage therapy phage

SCI

英语

其他

Ministry of Science and Technology of China[2018YFA0903600] ; Guangdong Provincial Key Laboratory of Synthetic Genomics[2019B030301006] ; Shenzhen Key Laboratory of Synthetic Genomics[ZDSYS201802061806209] ; Shenzhen Peacock Team Project[KQTD2016112915000294] ; International Collaborative Research Fund[GJHZ20180413181716797] ; Free Inquiry Fund[JCYJ20180305163929948] ; Shenzhen Key Medical Discipline construction Fund[SZXK045] ; Health Commission of Guangdong Province[A2019501]

Immunology ; Microbiology

Immunology ; Microbiology

WOS:000627753300001

FRONTIERS MEDIA SA

2-s2.0-85102429326

Scopus

1.Shenzhen Key Laboratory of Synthetic Genomics,Guangdong Provincial Key Laboratory of Synthetic Genomics,CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China
2.Department of Critical Care Medicine,Shenzhen People’s Hospital,The Second Clinical Medical College of Jinan University,The First Affiliated Hospital of South,University of Science and Technology),Shenzhen,China
3.Shenzhen People’s Hospital,Shenzhen Institute of Respiratory Diseases,Shenzhen,China
4.Bacteriology and Antibacterial Resistance Surveillance Laboratory,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China
5.Department of Geriatrics,Shenzhen People’s Hospital,The Second Clinical Medical College of Jinan University,The First Affiliated Hospital of South,University of Science and Technology),Shenzhen,China

Tan，Xin,Chen，Huaisheng,Zhang，Min,et al. Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease[J]. Frontiers in Cellular and Infection Microbiology,2021,11.

Tan，Xin.,Chen，Huaisheng.,Zhang，Min.,Zhao，Ying.,Jiang，Yichun.,...&Ma，Yingfei.(2021).Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease.Frontiers in Cellular and Infection Microbiology,11.

Tan，Xin,et al."Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease".Frontiers in Cellular and Infection Microbiology 11(2021).