Mutational Pattern in Multiple Pulmonary Nodules Are Associated With Early Stage Lung Adenocarcinoma

Dong，Shao Wei1,2; Li，Rong3; Cheng，Zhiqiang4; Liu，Dong Cheng1; Xia，Jinquan1; Xu，Jing4; Li，Shixuan5; Wang，Jian5; Yue，Yongjian6; Fan，Yingrui3; Cao，Yundi3; Dai，Lingyun7; Wang，Jigang7; Zhao，Pan1; Wang，Xin8; Xiao，Zhangang9; Qiu，Chen6; Wang，Guang Suo5; Zou，Chang1,2

2021-02-19

10.3389/fonc.2020.571521

Frontiers in Oncology   影响因子和分区

2234-943X

The clinical significance of mutation in multiple pulmonary nodules is largely limited by single gene mutation-directed analysis and lack of validation of gene expression profiles. New analytic strategy is urgently needed for comprehensive understanding of genomic data in multiple pulmonary nodules. In this study, we performed whole exome sequencing in 16 multiple lung nodules and 5 adjacent normal tissues from 4 patients with multiple pulmonary nodules and decoded the mutation information from a perspective of cellular functions and signaling pathways. Mutated genes as well as mutation patterns shared in more than two lesions were identified and characterized. We found that the number of mutations or mutated genes and the extent of protein structural changes caused by different mutations is positively correlated with the degree of malignancy. Moreover, the mutated genes in the nodules are associated with the molecular functions or signaling pathways related to cell proliferation and survival. We showed a developing pattern of quantity (the number of mutations/mutated genes) and quality (the extent of protein structural changes) in multiple pulmonary nodules. The mutation and mutated genes in multiple pulmonary nodules are associated with cell proliferation and survival related signaling pathways. This study provides a new perspective for comprehension of genomic mutational data and might shed new light on deciphering molecular evolution of early stage lung adenocarcinoma.

functional analysis mutation pathway analysis pulmonary nodules whole-exome sequencing

SCI

英语

第一 ; 通讯

WOS:000625484300001

2-s2.0-85102238963

Scopus

1.Clinical Medical Research Centre,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen People’s Hospital,Shenzhen,China
2.Shenzhen Public Service Platform on Tumor Precision Medicine and Molecular Diagnosis,Shenzhen,China
3.Department of Oncology,Taikang Xianlin Drum Tower Hospital,Nanjing University School of Medicine,Nanjing,China
4.Department of Pathology,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen People’s Hospital,Shenzhen,China
5.Department of Thoracic Surgery,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen People’s Hospital,Shenzhen,China
6.Department of Respiratory and Critical Medicine,Shenzhen People’s Hospital,Second Clinical Medical College of Jinan University,Shenzhen,China
7.Department of Geriatrics,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen People’s Hospital,Shenzhen,China
8.Department of Biomedical Sciences,City University of Hong Kong,Hong Kong
9.Key Laboratory of Medical Electrophysiology of Ministry of Education,School of Pharmacy,Southwestern Medical University,Luzhou,China

Dong，Shao Wei,Li，Rong,Cheng，Zhiqiang,et al. Mutational Pattern in Multiple Pulmonary Nodules Are Associated With Early Stage Lung Adenocarcinoma[J]. Frontiers in Oncology,2021,10.

Dong，Shao Wei.,Li，Rong.,Cheng，Zhiqiang.,Liu，Dong Cheng.,Xia，Jinquan.,...&Zou，Chang.(2021).Mutational Pattern in Multiple Pulmonary Nodules Are Associated With Early Stage Lung Adenocarcinoma.Frontiers in Oncology,10.

Dong，Shao Wei,et al."Mutational Pattern in Multiple Pulmonary Nodules Are Associated With Early Stage Lung Adenocarcinoma".Frontiers in Oncology 10(2021).