Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice

Kılıç，Kıvılcım1; Desjardins，Michèle2; Tang，Jianbo1,3; Thunemann，Martin1; Sunil，Smrithi1; Erdener，Şefik Evren1,4; Postnov，Dmitry D.1,5; Boas，David A.1; Devor，Anna1

2021-01-22

10.3389/fphys.2020.612678

Frontiers in Physiology   影响因子和分区

1664-042X

Chronic cranial windows allow for longitudinal brain imaging experiments in awake, behaving mice. Different imaging technologies have their unique advantages and combining multiple imaging modalities offers measurements of a wide spectrum of neuronal, glial, vascular, and metabolic parameters needed for comprehensive investigation of physiological and pathophysiological mechanisms. Here, we detail a suite of surgical techniques for installation of different cranial windows targeted for specific imaging technologies and their combination. Following these techniques and practices will yield higher experimental success and reproducibility of results.

awake chronic imaging mice multimodal neural vascular

SCI

英语

其他

WOS:000614747500001

2-s2.0-85100557686

Scopus

1.Biomedical Engineering,Boston University,Boston,United States
2.Centre de recherche du CHU de Québec,Université Laval,Quebec City,Canada
3.Department of Biomedical Engineering,SUSTech,Shenzhen,China
4.Institute of Neurological Sciences and Psychiatry,Ankara,Hacettepe Üniversitesi,Turkey
5.Department of Biomedical Sciences,University of Copenhagen,Copenhagen,Denmark

Kılıç，Kıvılcım,Desjardins，Michèle,Tang，Jianbo,et al. Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice[J]. Frontiers in Physiology,2021,11.

Kılıç，Kıvılcım.,Desjardins，Michèle.,Tang，Jianbo.,Thunemann，Martin.,Sunil，Smrithi.,...&Devor，Anna.(2021).Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice.Frontiers in Physiology,11.

Kılıç，Kıvılcım,et al."Chronic Cranial Windows for Long Term Multimodal Neurovascular Imaging in Mice".Frontiers in Physiology 11(2021).