The Synergy of Topographical Micropatterning and Ta|TaCu Bilayered Thin Film on Titanium Implants Enables Dual-Functions of Enhanced Osteogenesis and Anti-Infection

Zhu，Mingyu1; Fang，Ju1; Li，Yulei1; Zhong，Chuanxin1; Feng，Shihui1; Ge，Xiang2; Ye，Haixia1; Wang，Xiaofei1; Zhu，Weiwei1; Lu，Xiong3; Ren，Fuzeng1

2021

10.1002/adhm.202002020

Advanced Healthcare Materials   影响因子和分区

2192-2640

2192-2659

Poor osteogenesis and implant-associated infection are the two leading causes of failure for dental and orthopedic implants. Surface design with enhanced osteogenesis often fails in antibacterial activity, or vice versa. Herein, a surface design strategy, which overcomes this trade-off via the synergistic effects of topographical micropatterning and a bilayered nanostructured metallic thin film is presented. A specific microgrooved pattern is fabricated on the titanium surface, followed by sequential deposition of a nanostructured copper (Cu)-containing tantalum (Ta) (TaCu) layer and a pure Ta cap layer. The microgrooved patterns coupled with the nanorough Ta cap layer shows strong contact guidance to preosteoblasts and significantly enhances the osteogenic differentiation in vitro, while the controlled local sustained release of Cu ions is responsible for high antibacterial activity. Importantly, rat calvarial defect models in vivo further confirm that the synergy of microgrooved patterns and the Ta|TaCu bilayered thin film on titanium surface could effectively promote bone regeneration. The present effective and versatile surface design strategy provides significant insight into intelligent surface engineering that can control biological response at the site of healing in dental and orthopedic implants.

antibacterial activity metallic thin films osteogenic differentiation surface topography

SCI ; EI

英语

第一 ; 通讯

WOS:000627613800001

20211110074707

Binary alloys ; Copper alloys ; Dental alloys ; Economic and social effects ; Heavy ions ; Metal implants ; Tissue regeneration

Biomedical Engineering:461.1 ; Dental Equipment and Supplies:462.3 ; Copper Alloys:544.2 ; Social Sciences:971

2-s2.0-85102281647

Scopus

1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education,School of Mechanical Engineering,Tianjin University,Tianjin,300354,China
3.Key Lab of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,610000,China

Zhu，Mingyu,Fang，Ju,Li，Yulei,et al. The Synergy of Topographical Micropatterning and Ta|TaCu Bilayered Thin Film on Titanium Implants Enables Dual-Functions of Enhanced Osteogenesis and Anti-Infection[J]. Advanced Healthcare Materials,2021,10.

Zhu，Mingyu.,Fang，Ju.,Li，Yulei.,Zhong，Chuanxin.,Feng，Shihui.,...&Ren，Fuzeng.(2021).The Synergy of Topographical Micropatterning and Ta|TaCu Bilayered Thin Film on Titanium Implants Enables Dual-Functions of Enhanced Osteogenesis and Anti-Infection.Advanced Healthcare Materials,10.

Zhu，Mingyu,et al."The Synergy of Topographical Micropatterning and Ta|TaCu Bilayered Thin Film on Titanium Implants Enables Dual-Functions of Enhanced Osteogenesis and Anti-Infection".Advanced Healthcare Materials 10(2021).