Bioinspired Highly Anisotropic, Ultrastrong and Stiff, and Osteoconductive Mineralized Wood Hydrogel Composites for Bone Repair

Wang，Xiaofei1,2; Fang，Ju1; Zhu，Weiwei1; Zhong，Chuanxin1,3; Ye，Dongdong4; Zhu，Mingyu1; Lu，Xiong5; Zhao，Yusheng2; Ren，Fuzeng1

2021

10.1002/adfm.202010068

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Anisotropic hydrogels mimicking the biological tissues with directional functions play essential roles in damage-tolerance, cell guidance and mass transport. However, conventional synthetic hydrogels often have an isotropic network structure, insufficient mechanical properties and lack of osteoconductivity, which greatly limit their applications for bone repair. Herein, inspired by natural bone and wood, a biomimetic strategy is presented to fabricate highly anisotropic, ultrastrong and stiff, and osteoconductive hydrogel composites via impregnation of biocompatible hydrogels into the delignified wood followed by in situ mineralization of hydroxyapatite (HAp) nanocrystals. The well-aligned cellulose nanofibrils endow the composites with highly anisotropic structural and mechanical properties. The strong intermolecular bonds of the aligned cellulose fibrils and hydrogel/wood interaction, and the reinforcing nanofillers of HAp enable the composites remarkable tensile strength of 67.8 MPa and elastic modulus of 670 MPa, three orders of magnitude higher than those of conventional alginate hydrogels. More importantly, the biocompatible hydrogel together with aligned HAp nanocrystals could effectively promote osteogenic differentiation in vitro and induce bone formation in vivo. The bone ingrowth into the hydrogel composite scaffold also yields good osteointegration. This study provides a low-cost, eco-friendly, feasible, and scalable approach for fabricating anisotropic, strong, stiff, hydrophilic, and osteoconductive hydrogel composites for bone repair.

anisotropic hydrogels bioinspired materials bone repair high strength osteoconductivity

SCI ; EI

英语

ESI高被引 ; NI期刊 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引 ; ESI高被引

第一 ; 通讯

WOS:000625726800001

20211010049312

Anisotropy ; Biocompatibility ; Biomechanics ; Biomimetics ; Bone ; Cellulose ; Cellulose nanocrystals ; Composite structures ; Hydroxyapatite ; Repair ; Tensile strength

Structural Members and Shapes:408.2 ; Bioengineering and Biology:461 ; Chemical Products Generally:804 ; Inorganic Compounds:804.2 ; Cellulose, Lignin and Derivatives:811.3 ; Maintenance:913.5 ; Physical Properties of Gases, Liquids and Solids:931.2

MATERIALS SCIENCE

2-s2.0-85102085126

Scopus

1.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Academy for Advanced Interdisciplinary Studies (AAIS),Southern University of Science and Technology,Shenzhen,518055,China
3.Institute for Advancing Translational Medicine in Bone and Joint Diseases,School of Chinese Medicine,Hong Kong Baptist University,999077,Hong Kong
4.School of Textile Materials and Engineering,Wuyi University,Jiangmen,529020,China
5.Key Lab of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,621000,China

Wang，Xiaofei,Fang，Ju,Zhu，Weiwei,et al. Bioinspired Highly Anisotropic, Ultrastrong and Stiff, and Osteoconductive Mineralized Wood Hydrogel Composites for Bone Repair[J]. ADVANCED FUNCTIONAL MATERIALS,2021,31.

Wang，Xiaofei.,Fang，Ju.,Zhu，Weiwei.,Zhong，Chuanxin.,Ye，Dongdong.,...&Ren，Fuzeng.(2021).Bioinspired Highly Anisotropic, Ultrastrong and Stiff, and Osteoconductive Mineralized Wood Hydrogel Composites for Bone Repair.ADVANCED FUNCTIONAL MATERIALS,31.

Wang，Xiaofei,et al."Bioinspired Highly Anisotropic, Ultrastrong and Stiff, and Osteoconductive Mineralized Wood Hydrogel Composites for Bone Repair".ADVANCED FUNCTIONAL MATERIALS 31(2021).