Reversing Bacterial Resistance to Gold Nanoparticles by Size Modulation

Zheng，Wenshu1; Jia，Yuexiao1; Zhao，Yuyun1; Zhang，Jiangjiang1; Xie，Yangzhouyun1; Wang，Le1; Zhao，Xiaohui1; Liu，Xiaoyan1; Tang，Rongbing1; Chen，Wenwen2; Jiang，Xingyu1

2021

10.1021/acs.nanolett.0c04451

NANO LETTERS   影响因子和分区

1530-6984

1530-6992

One major frustration in developing antibiotics is that bacteria can quickly develop resistance that would require an entirely new cycle of research and clinical testing to overcome. Although plenty of bactericidal nanomaterials have been developed against increasingly severe superbugs, few reports have studied the resistance to these nanomaterials. Herein, we show that antibacterial 4,6-diamino-2-pyrimidine thiol (DAPT)-capped gold nanoparticles (AuDAPTs) can induce a 16-fold increased minimum inhibitory concentration (MIC) of E. coli only after very long term exposure (183 days), without developing cross-resistance to commercialized antibiotics. Strikingly, we recovered the bactericidal activities of AuDAPTs to the resistant strain by tuning the sizes of AuDAPTs without employing new chemicals. Such slow, easy-to-handle resistance induced by AuDAPTs is unprecedented compared to traditional antibiotics or other nanomaterials. In addition to the novel antibacterial activities and biocompatibilities, our approach will accelerate the development of gold nanomaterial-based therapeutics against multi-drug-resistant (MDR) bacterial infections.

bacterial resistance gold nanoparticles membrane disruption size modulation

SCI ; EI

英语

NI论文

第一 ; 通讯

National Natural Science Foundation of China[21761142006,21535001,81730051] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; National KeyR&DProgram of China[2018YFA0902600] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Shenzhen Bay Laboratory[SZBL2019062801004]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000629091100013

AMER CHEMICAL SOC

20211010027942

Antibiotics ; Biocompatibility ; Clinical research ; Drug delivery ; Escherichia coli ; Fiber optic sensors ; Metal nanoparticles ; Nanostructured materials

Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Fiber Optics:741.1.2 ; Nanotechnology:761

MATERIALS SCIENCE

2-s2.0-85101909738

Scopus

1.Department of Biomedical Engineering,Shenzhen Bay Laboratory,Southern University of Science and Technology,Nanshan District, Shenzhen, Guangdong,No. 1088, Xueyuan Road, Xili,518055,China
2.Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,School of Biomedical Engineering,Health Science Center,Shenzhen University,Shenzhen, Guangdong,518060,China

Zheng，Wenshu,Jia，Yuexiao,Zhao，Yuyun,et al. Reversing Bacterial Resistance to Gold Nanoparticles by Size Modulation[J]. NANO LETTERS,2021,21(5):1992-2000.

Zheng，Wenshu.,Jia，Yuexiao.,Zhao，Yuyun.,Zhang，Jiangjiang.,Xie，Yangzhouyun.,...&Jiang，Xingyu.(2021).Reversing Bacterial Resistance to Gold Nanoparticles by Size Modulation.NANO LETTERS,21(5),1992-2000.

Zheng，Wenshu,et al."Reversing Bacterial Resistance to Gold Nanoparticles by Size Modulation".NANO LETTERS 21.5(2021):1992-2000.