Conductive Cellulose Bio-Nanosheets Assembled Biostable Hydrogel for Reliable Bioelectronics

Yan，Liwei1; Zhou，Ting1; Han，Lu2; Zhu，Mingyu3; Cheng，Zhuo3; Li，Da1; Ren，Fuzeng3; Wang，Kefeng4; Lu，Xiong1

2021

10.1002/adfm.202010465

ADVANCED FUNCTIONAL MATERIALS   影响因子和分区

1616-301X

1616-3028

Biostable electronic materials that can maintain their super mechanical and conductive properties, even when exposed to biofluids, are the fundamental basis for designing reliable bioelectronic devices. Herein, cellulose-derived conductive 2D bio-nanosheets as electronic base materials are developed and assembled into a conductive hydrogel with ultra-high biostability, capable of surviving in harsh physiological environments. The bio-nanosheets are synthesized by guiding the in situ regeneration of cellulose crystal into a 2D planar structure using the polydopamine-reduced-graphene oxide as supporting templates. The nanosheet-assembled hydrogel exhibits stable electrical and mechanical performances after undergoing aqueous immersion and in vivo implantation. Thus, the hydrogel-based bioelectronic devices are able to conformally integrate with the human body and stably record electrophysiological signals. Owing to its tissue affinity, the hydrogel further serves as an “E-skin,” which employs electrotherapy to aid in the faster healing of chronic wounds in diabetic mice through transcutaneous electrical stimulation. The nanosheet-assembled biostable, conductive, flexible, and cell/tissue affinitive hydrogel lays a foundation for designing electronically and mechanically reliable bioelectronic devices.

cellulose conductive hydrogels E-skin graphene oxides polydopamine

SCI ; EI

英语

NI论文

其他

WOS:000620689700001

20210909982820

Body fluids ; Cellulose ; Crystal structure ; Electrophysiology ; Electrotherapeutics ; Functional electric stimulation ; Graphene ; Mammals ; Nanosheets

Bioengineering and Biology:461 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Cellulose, Lignin and Derivatives:811.3 ; Solid State Physics:933 ; Crystal Lattice:933.1.1

MATERIALS SCIENCE

2-s2.0-85101229337

Scopus

1.Key Lab of Advanced Technologies of Materials Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu,610031,China
2.School of Medicine and Pharmaceutics,Ocean University of China,Qingdao,266003,China
3.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,518055,China
4.National Engineering Research Center for Biomaterials,Genome Research Center for Biomaterials,Sichuan University,Chengdu,610064,China

Yan，Liwei,Zhou，Ting,Han，Lu,et al. Conductive Cellulose Bio-Nanosheets Assembled Biostable Hydrogel for Reliable Bioelectronics[J]. ADVANCED FUNCTIONAL MATERIALS,2021,31.

Yan，Liwei.,Zhou，Ting.,Han，Lu.,Zhu，Mingyu.,Cheng，Zhuo.,...&Lu，Xiong.(2021).Conductive Cellulose Bio-Nanosheets Assembled Biostable Hydrogel for Reliable Bioelectronics.ADVANCED FUNCTIONAL MATERIALS,31.

Yan，Liwei,et al."Conductive Cellulose Bio-Nanosheets Assembled Biostable Hydrogel for Reliable Bioelectronics".ADVANCED FUNCTIONAL MATERIALS 31(2021).