circTulp4 functions in Alzheimer's disease pathogenesis by regulating its parental gene, Tulp4

Ma，Nana1,2,6; Pan，Jie1,2; Wen，Yi3; Wu，Qi1; Yu，Bo4,5; Chen，Xi3; Wan，Jun1,2,3; Zhang，Wei1,2

2021

10.1016/j.ymthe.2021.02.008

MOLECULAR THERAPY   影响因子和分区

1525-0016

1525-0024

Alzheimer's disease (AD)—one of the most common neurodegenerative diseases worldwide—impairs cognition, memory, and language ability and causes dementia. However, AD pathogenesis remains poorly elucidated. Recently, a potential link between AD and circular RNAs (circRNAs) has been uncovered, but only a few circRNAs that might be involved in AD have been identified. Here, we systematically investigated circRNAs in the APP/PS1 model mouse brain through deep RNA sequencing. We report that circRNAs are markedly enriched in the brain and that several circRNAs exhibit differential expression between wild-type and APP/PS1 mice. We characterized one abundant circRNA, circTulp4, derived from Intron1 of the gene Tulp4. Our results indicate that circTulp4 predominantly localizes in the nucleus and interacts with U1 small nuclear ribonucleoprotein particle (snRNP) and RNA polymerase II to modulate the transcription of its parental gene, Tulp4, and thereby regulate the function of the nervous system, and might participate in the development of AD. Recently, a potential link between AD and circular RNAs (circRNAs) has been uncovered. Wan et al. now show that circTulp4 predominantly localizes in the nucleus and interacts with U1 snRNP and RNA polymerase II to modulate the transcription of its parental gene, Tulp4, and might participate in the development of AD.

Alzheimer's disease circRNA circTulp4 neuronal differentiation Tulp4 U1 snRNP

SCI

英语

通讯

WOS:000658394600005

CLINICAL MEDICINE

2-s2.0-85101215110

Scopus

1.Greater Bay Biomedical Innocenter,Shenzhen Bay Laboratory,Shenzhen,China
2.Shenzhen Key Laboratory for Neuronal Structural Biology,Biomedical Research Institute,Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center,Shenzhen,China
3.Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,China
4.Shenzhen Key Laboratory for Translational Medicine of Dermatology,Biomedical Research Institute,Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center,Shenzhen,China
5.Department of Dermatology,Peking University Shenzhen Hospital,Shenzhen,China
6.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Beijing,China

Ma，Nana,Pan，Jie,Wen，Yi,et al. circTulp4 functions in Alzheimer's disease pathogenesis by regulating its parental gene, Tulp4[J]. MOLECULAR THERAPY,2021.

Ma，Nana.,Pan，Jie.,Wen，Yi.,Wu，Qi.,Yu，Bo.,...&Zhang，Wei.(2021).circTulp4 functions in Alzheimer's disease pathogenesis by regulating its parental gene, Tulp4.MOLECULAR THERAPY.

Ma，Nana,et al."circTulp4 functions in Alzheimer's disease pathogenesis by regulating its parental gene, Tulp4".MOLECULAR THERAPY (2021).